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MPI-0479605

Catalog No.: 62907
Cas No.: 1246529-32-7
Purity : >98% by HPLC 
62907 - MPI-0479605 | CAS 1246529-32-7

Catalog number : 62907

CAS number : 1246529-32-7

分子式 : C22H29N7O 

分子量 : 407.51 

Iupac 化学名称 : N6-cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine 

Smile : C1(CCCCC1)NC1=C2N=CNC2=NC(=N1)NC1=C(C=C(C=C1)N1CCOCC1)C

InChiKey : OVJBNYKNHXJGSA-UHFFFAOYSA-N

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同义词MPI 0479605,MPI0479605 
英文同义词MPI 0479605,MPI0479605 
分子式C22H29N7O 
分子量407.51 
外观crystalline solid 
纯度>98% by HPLC 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
SmileC1(CCCCC1)NC1=C2N=CNC2=NC(=N1)NC1=C(C=C(C=C1)N1CCOCC1)C
InChiKeyOVJBNYKNHXJGSA-UHFFFAOYSA-N
InChiInChI=1S/C22H29N7O/c1-15-13-17(29-9-11-30-12-10-29)7-8-18(15)26-22-27-20-19(23-14-24-20)21(28-22)25-16-5-3-2-4-6-16/h7-8,13-14,16H,2-6,9-12H2,1H3,(H3,23,24,25,26,27,28)
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MPI-0479605, a small-molecule inhibitor of the mitotic kinase Mps1.Cells treated with MPI-0479605 undergo aberrant mitosis, resulting in aneuploidy and formation of micronuclei. In cells with wild-type p53, this promotes the induction of a postmitotic checkpoint characterized by the ATM- and RAD3-related-dependent activation of the p53-p21 pathway. In both wild-type and p53 mutant cells lines, there is a growth arrest and inhibition of DNA synthesis. Subsequently, cells undergo mitotic catastrophe and/or an apoptotic response. In xenograft models, MPI-0479605 inhibits tumor growth, suggesting that drugs targeting Mps1 may have utility as novel cancer therapeutics.

 

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