ML192
ML192, also known as MLS000526305 and CID1434953, is a selective ligands for GPR55. The orphan G protein coupled receptor, ML192 (CID1434953) with 1080 nM potency for GPR55 and >45-fold antagonist and agonist selectivity against GPR35, CB1 and CB2. GPR55 has gained notoriety because of its putative identification as a cannabinoid receptor subtype. The significance of this assignment should not be underestimated given the importance of cannabinoids to drug abuse and the potential utility of cannabinoid ligands in treating behavioral disorders leading to conditions such as obesity.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | ML192 |
|---|---|
| Iupac 化学名称 | furan-2-yl(4-(2-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)piperazin-1-yl)methanone |
| 同义词 | ML192; ML 192; ML-192; CID1434953; CID-1434953; CID 1434953; MLS000526305. |
| 英文同义词 | ML192; ML 192; ML-192; CID1434953; CID-1434953; CID 1434953; MLS000526305. |
| 分子式 | C20H22N4O2S |
| 分子量 | 382.48 |
| Smile | CC1=NC(N2CCN(CC2)C(=O)C3=CC=CO3)=C4C(SC5=C4CCCC5)=N1 |
| InChiKey | GDPDARVUXXOYAJ-UHFFFAOYSA-N |
| InChi | InChI=1S/C20H22N4O2S/c1-13-21-18(17-14-5-2-3-7-16(14)27-19(17)22-13)23-8-10-24(11-9-23)20(25)15-6-4-12-26-15/h4,6,12H,2-3,5,7-11H2,1H3 |
| Cas号 | 460331-61-7 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 固体粉末 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 短期（几天到几周）为0-4摄氏度，长期（几个月）为-20摄氏度 |
| 可溶性 | 溶于DMSO |
| 处理方式 | |
| 运输条件 | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周. |
| 海关编码 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Kotsikorou E, Sharir H, Shore DM, Hurst DP, Lynch DL, Madrigal KE,
Heynen-Genel S, Milan LB, Chung TD, Seltzman HH, Bai Y, Caron MG, Barak LS,
Croatt MP, Abood ME, Reggio PH. Identification of the GPR55 antagonist binding
site using a novel set of high-potency GPR55 selective ligands. Biochemistry.
2013 Dec 31;52(52):9456-69. doi: 10.1021/bi4008885. Epub 2013 Dec 17. PubMed
PMID: 24274581; PubMed Central PMCID: PMC3970910.
2: Heynen-Genel S, Dahl R, Shi S, Milan L, Hariharan S, Sergienko E, Hedrick M,
Dad S, Stonich D, Su Y, Vicchiarelli M, Mangravita-Novo A, Smith LH, Chung TDY,
Sharir H, Caron MG, Barak LS, Abood ME. Screening for Selective Ligands for GPR55
- Antagonists. 2010 Oct 30 [updated 2011 May 26]. Probe Reports from the NIH
Molecular Libraries Program [Internet]. Bethesda (MD): National Center for
Biotechnology Information (US); 2010-. Available from
http://www.ncbi.nlm.nih.gov/books/NBK66153/
PubMed PMID: 22091481.
