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MK8745

Catalog No.: 122819
Cas No.: 885325-71-3
Purity : 98% 
122819 - MK8745 | CAS 885325-71-3

Catalog number : 122819

CAS number : 885325-71-3

分子式 : C20H19ClFN5OS 

分子量 : 431.914 

Iupac 化学名称 : (3-chloro-2-fluorophenyl)-[4-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]piperazin-1-yl]methanone 

Smile : C1CN(CCN1CC2=NC(=CC=C2)NC3=NC=CS3)C(=O)C4=C(C(=CC=C4)Cl)F

InChiKey : YCRFPWKUUNKNDN-UHFFFAOYSA-N

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同义词MK-8745; MK 8745 
英文同义词MK-8745; MK 8745 
分子式C20H19ClFN5OS 
分子量431.914 
外观Solid powder 
纯度98% 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileC1CN(CCN1CC2=NC(=CC=C2)NC3=NC=CS3)C(=O)C4=C(C(=CC=C4)Cl)F
InChiKeyYCRFPWKUUNKNDN-UHFFFAOYSA-N
InChiInChI=1S/C20H19ClFN5OS/c21-16-5-2-4-15(18(16)22)19(28)27-10-8-26(9-11-27)13-14-3-1-6-17(24-14)25-20-23-7-12-29-20/h1-7,12H,8-11,13H2,(H,23,24,25)
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MK-8745 is a novel Aurora-A specific inhibitor. MK8745 induced apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.
 

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