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MK-4101

Catalog No.: 6111008
Cas No.: 935273-79-3
Purity : 98% 
6111008 - MK-4101 | CAS 935273-79-3

Catalog number : 6111008

CAS number : 935273-79-3

分子式 : C24H24F5N5O 

分子量 : 493.47 

Iupac 化学名称 : MK-4101 

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同义词MK 4101, MK4101 
英文同义词MK 4101, MK4101 
分子式C24H24F5N5O 
分子量493.47 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
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MK-4101 is a potent SMO Inhibitor of the Hedgehog Pathway

MK-4101 is a potent SMO Inhibitor of the Hedgehog Pathway, highly active against Medulloblastoma and Basal Cell Carcinoma. target:SMO In vivo: MK-4101 was highly efficacious against primary medulloblastoma and BCC developing in the cerebellum and skin of Ptch1+/- mice. In vitro: MK-4101 induce deregulation of cell cycle and block of DNA replication in tumors. MK-4101 targets the Hh pathway in tumor cells, showing the maximum inhibitory effect on Gli1. MK-4101 also induce deregulation of cell cycle and block of DNA replication in tumors.

 

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