武汉永璨生物科技有限公司
+86-17702719238 sales@sun-shinechem.com

MK 2206

编号: 51505
Cas号: 1032350-13-2
纯度: 98% 

MK-2206 (Merck, Whitehouse Station, NJ) is an investigational oral allosteric AKT inhibitor (Appendix Fig A1, online only) with nanomolar potency against purified recombinant human AKT1 (half maximal inhibitory concentration [IC50], 5 nmol/L) and AKT2 enzymes (IC50, 12 nmol/L) but lower potency against human AKT3 (IC50, 65 nmol/L). MK-2206 inhibits phosphorylation at both Thr308 and Ser473 residues of AKT and demonstrates greater than 100-fold selectivity for AKT against 256 other kinases.MK-2206 has in vitro and in vivo antitumor activity as a single agent and enhances the preclinical activity of conventional cytotoxics and other molecular targeted therapies. These promising data led to a phase I dose-escalation study of MK-2206 in patients with advanced solid tumors.

 

仅供研究使用。 我们不向患者出售。

化学信息

名称MK 2206
Iupac 化学名称8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-8,9-dihydro-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride 
同义词MK-2206; MK2206; MK 2206; MK-2206 dihydrochloride; MK-2206 dihydrochloride; MK2206 dihydrochloride; MK 2206 dihydrochloride; MK2206 hydrochloride. 
英文同义词MK-2206; MK2206; MK 2206; MK-2206 dihydrochloride; MK-2206 dihydrochloride; MK2206 dihydrochloride; MK 2206 dihydrochloride; MK2206 hydrochloride. 
分子式C25H23Cl2N5O 
分子量480.39 
SmileO=C1NN=C2C3=CC(C4=CC=CC=C4)C(C5=CC=C(C6(N)CCC6)C=C5)N=C3C=CN21
InChiKeyATHMWHVQBQZTAB-UHFFFAOYSA-N
InChiInChI=1S/C25H23N5O/c26-25(12-4-13-25)18-9-7-17(8-10-18)22-19(16-5-2-1-3-6-16)15-20-21(27-22)11-14-30-23(20)28-29-24(30)31/h1-3,5-11,14-15,19,22H,4,12-13,26H2,(H,29,31)
Cas号1032350-13-2
相关CAS号

订购信息

包装价格库存纯度备货期
大货询价询价询价
Request Bulk Quote Download MSDS 电话 : +86-177 0271 9238   Email : sales@sun-shinechem.com
外观性状Yellow solid powder 
纯度98% 
存储3 years -20ºCpowder 
可溶性Soluble in DMSO 
处理方式
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

51505 - MK 2206 | CAS 1032350-13-2

快速订购

Change