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MGCD-265-analog

Catalog No.: 111013
Cas No.: 875337-44-3
Purity : 98% by HPLC/HNMR 
111013 - MGCD-265-analog | CAS 875337-44-3

Catalog number : 111013

CAS number : 875337-44-3

分子式 : C26H20FN5O2S2 

分子量 : 517.60 

Iupac 化学名称 : N-((3-fluoro-4-((2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)carbamothioyl)-2-phenylacetamide 

Smile : O=C(NC(NC1=CC=C(OC2=C3C(C=C(C4=CN(C)C=N4)S3)=NC=C2)C(F)=C1)=S)CC5=CC=CC=C5

InChiKey : UFICVEHDQUKCEA-UHFFFAOYSA-N

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同义词MGCD265;MGCD 265 
英文同义词MGCD265;MGCD 265 
分子式C26H20FN5O2S2 
分子量517.60 
外观crystalline solid 
纯度98% by HPLC/HNMR 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 6 months-80ºCin solvent 
运输条件Shipped under ambient temperature. 
SmileO=C(NC(NC1=CC=C(OC2=C3C(C=C(C4=CN(C)C=N4)S3)=NC=C2)C(F)=C1)=S)CC5=CC=CC=C5
InChiKeyUFICVEHDQUKCEA-UHFFFAOYSA-N
InChiInChI=1S/C26H20FN5O2S2/c1-32-14-20(29-15-32)23-13-19-25(36-23)22(9-10-28-19)34-21-8-7-17(12-18(21)27)30-26(35)31-24(33)11-16-5-3-2-4-6-16/h2-10,12-15H,11H2,1H3,(H2,30,31,33,35)
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MGCD265 is a tyrosine kinase inhibitor that selectively targets MET and Axl. Genetic alterations in these targets have been implicated as drivers of tumor growth and disease progression in NSCLC, HNSCC, gastroesophageal cancer and other solid tumors. MET and Axl are also implicated as drivers of tumor progression in patients whose tumors have become resistant to EGFR inhibitors such as Tarceva®, Iressa®and Erbitux®. Therefore, the combination of MGCD265 with EGFR inhibitors is designed to treat patients who have become resistant to agents targeting EGFR.

 

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