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MCC950 sodium

Catalog No.: 6111014
Cas No.: 256373-96-3
Purity : 98% 
6111014 - MCC950 sodium | CAS 256373-96-3

Catalog number : 6111014

CAS number : 256373-96-3

分子式 : C20H23N2NaO5S 

分子量 : 426.46 

Iupac 化学名称 : MCC950 sodium 

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同义词MCC950 , CP-456773 
英文同义词MCC950 , CP-456773 
分子式C20H23N2NaO5S 
分子量426.46 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
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MCC950 (CP 456773) sodium is a potent, selective, small molecule inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs

MCC950 blocked canonical and noncanonical NLRP3 activation at nanomolar concentrations.
MCC950 specifically inhibited activation of NLRP3 but not the AIM2, NLRC4 or NLRP1
inflammasomes. MCC950 reduced interleukin-1 (IL-1) production in vivo and attenuated the
severity of experimental autoimmune encephalomyelitis (EAE), a disease model of multiple
sclerosis.

 

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