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MAC-545496

编号: 2071611
Cas号: 838810-96-1
纯度: 98% Min.

MAC-545496 is potent GraR inhibitor (glycopeptide-resistance-associated protein R). MAC-545496 reverses β-lactam resistance in the community-acquired MRSA USA300 strain. MAC-545496 could also serve as an antivirulence agent alone; it attenuates MRSA virulence in Galleria mellonella larvae. MAC-545496 inhibits biofilm formation and abrogates intracellular survival in macrophages. Mechanistic characterization revealed MAC-545496 to be a nanomolar inhibitor of GraR, a regulator that responds to cell-envelope stress and is an important virulence factor and determinant of antibiotic resistance. MAC-545496 has value as a research tool to probe the GraXRS regulatory system and as an antibacterial lead series of a mechanism to combat drug-resistant Staphylococcal infections.

仅供研究使用。 我们不向患者出售。

化学信息

名称 MAC-545496
Iupac 化学名称N-((5-chloropyridin-2-yl)carbamothioyl)-3-nitro-4-(piperidin-1-yl)benzamide
同义词 MAC-545496; MAC 545496; MAC545496;
英文同义词 MAC-545496; MAC 545496; MAC545496;
分子式C18H18ClN5O3S
分子量419.884
SmileO=C(NC(NC1=NC=C(Cl)C=C1)=S)C2=CC=C(N3CCCCC3)C([N+]([O-])=O)=C2
InChiKeyAFOKREIUUQFDNW-UHFFFAOYSA-N
InChi InChI=1S/C18H18ClN5O3S/c19-13-5-7-16(20-11-13)21-18(28)22-17(25)12-4-6-14(15(10-12)24(26)27)23-8-2-1-3-9-23/h4-7,10-11H,1-3,8-9H2,(H2,20,21,22,25,28)
Cas号838810-96-1
相关CAS号

订购信息

包装价格库存纯度备货期
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外观性状固体粉末
纯度98% Min.
存储短期(几天到几周)为0-4摄氏度,长期(几个月)为-20摄氏度
可溶性可溶于DMSO
处理方式
运输条件作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

El-Halfawy OM, Czarny TL, Flannagan RS, et al. Discovery of an antivirulence compound that reverses β-lactam resistance in MRSA. Nat Chem Biol. 2020;16(2):143–149. doi:10.1038/s41589-019-0401-8

化学结构

2071611 -  MAC-545496 | CAS 838810-96-1

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