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Lonafarnib

Catalog No.: 16071008
Cas No.: 193275-84-2
Purity : 98% by HPLC 
16071008 - Lonafarnib | CAS 193275-84-2

Catalog number : 16071008

CAS number : 193275-84-2

分子式 : C27H31Br2ClN4O2 

分子量 : 638.82 

Iupac 化学名称 : 4-(2-(4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-yl)-1-piperidinyl)-2-oxoethyl)-1-piperidinecarboxamide 

Smile : ClC=1C=C(C2=C(CCC=3C(=NC=C(C3)Br)C2C2CCN(CC2)C(CC2CCN(CC2)C(=O)N)=O)C1)Br

InChiKey : DHMTURDWPRKSOA-UHFFFAOYSA-N

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同义词US brand name: Sarasar 
英文同义词US brand name: Sarasar 
分子式C27H31Br2ClN4O2 
分子量638.82 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileClC=1C=C(C2=C(CCC=3C(=NC=C(C3)Br)C2C2CCN(CC2)C(CC2CCN(CC2)C(=O)N)=O)C1)Br
InChiKeyDHMTURDWPRKSOA-UHFFFAOYSA-N
InChiInChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)
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 Lonafarnib is a farnesyl transferase inhibitor. Structurely, it is also a synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme involved in the post-translational modification and activation of Ras proteins. Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis. Mutated ras proteins have been found in a wide range of human cancers. Check for active clinical trials or closed clinical trials using this agent. 

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