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Lomitapide free base

Catalog No.: 16123035
Cas No.: 182431-12-5
Purity : 98% 
16123035 - Lomitapide free base | CAS 182431-12-5

Catalog number : 16123035

CAS number : 182431-12-5

分子式 : C39H37F6N3O2 

分子量 : 693.73442 

Iupac 化学名称 : Lomitapide free base 

Smile : c1ccc(c(c1)c2ccc(cc2)C(F)(F)F)C(=O)NC3CCN(CC3)CCCCC4(c5ccccc5-c6c4cccc6)C(=O)NCC(F)(F)F

InChiKey : MBBCVAKAJPKAKM-UHFFFAOYSA-N

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同义词AEGR 733; AEGR733; AEGR-733; BMS 201038; BMS-201038; BMS201038; BMS 201038-01. Lomitapide mesylate. Brand name: Juxtapid; Lojuxta. 
英文同义词AEGR 733; AEGR733; AEGR-733; BMS 201038; BMS-201038; BMS201038; BMS 201038-01. Lomitapide mesylate. Brand name: Juxtapid; Lojuxta. 
分子式C39H37F6N3O2 
分子量693.73442 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
Smilec1ccc(c(c1)c2ccc(cc2)C(F)(F)F)C(=O)NC3CCN(CC3)CCCCC4(c5ccccc5-c6c4cccc6)C(=O)NCC(F)(F)F
InChiKeyMBBCVAKAJPKAKM-UHFFFAOYSA-N
InChiInChI=1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)
MDLMFCD16620494
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Lomitapide is a MTP inhibitor. Lomitapid is a novel agent for the treatment of homozygous familial hypercholesterolemia. Lomitapide is an orally active inhibitor of microsomal triglyceride transfer protein that is indicated as an adjunct to a low-fat diet and other lipid-lowering treatments, including LDL apheresis where available for the reduction of LDL-C, total cholesterol, apolipoprotein B, and non-high-density lipoprotein cholesterol in adult patients with HoFH. 

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