Lometrexol disodium
编号: 16123034
Cas号: 106400-81-1
纯度: 98%
Lometrexol is a folate analog antimetabolite with antineoplastic activity. As the 6R diastereomer of 5,10-dideazatetrahydrofolate, lometrexol inhibits glycinamide ribonucleotide formyltransferase (GARFT), the enzyme that catalyzes the first step in the de novo purine biosynthetic pathway, thereby inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation. The agent has been shown to be active against tumors that are resistant to the folate antagonist methotrexate. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Lometrexol disodium |
|---|---|
| Iupac 化学名称 | Lometrexol disodium |
| 同义词 | LY 264618; LY-264618; LY264618; NSC722969; NSC-722969; NSC-722969. (6R)DDATHF; LMTX; DDATHF disodium; Lometrexol |
| 英文同义词 | LY 264618; LY-264618; LY264618; NSC722969; NSC-722969; NSC-722969. (6R)DDATHF; LMTX; DDATHF disodium; Lometrexol |
| 分子式 | C21H23N5Na2O6 |
| 分子量 | 487.42 |
| Smile | c1cc(ccc1CC[C@@H]2Cc3c(=O)[nH]c(nc3NC2)N)C(=O)N[C@@H](CCC(=O)O)C(=O)O |
| InChiKey | ZUQBAQVRAURMCL-DOMZBBRYSA-N |
| InChi | InChI=1S/C21H25N5O6/c22-21-25-17-14(19(30)26-21)9-12(10-23-17)2-1-11-3-5-13(6-4-11)18(29)24-15(20(31)32)7-8-16(27)28/h3-6,12,15H,1-2,7-10H2,(H,24,29)(H,27,28)(H,31,32)(H4,22,23,25,26,30)/t12-,15+/m1/s1 |
| Cas号 | 106400-81-1 |
| MDL | MFCD00866319 |
| 相关CAS号 |
订购信息
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