Linperlisib free base
编号: 2061309
Cas号: 1702816-75-8
纯度: 98% Min.
Linperlisib, also known as YY-20394 and PI3Kδ-IN-2, is a potent and selective PI3Kδ inhibitor. YY-20394 significantly inhibited primary tumor growth in immune-competent mice with 4T1 and CT26 tumors, as well as 4T1 lung metastasis with dose dependency. YY-20394 significantly inhibited T cell differentiation into Treg both in mouse splenocyte and in human primary CD4+ T cells, and was especially potent inhibiting their IL-10 secretion in vitro.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Linperlisib free base |
|---|---|
| Iupac 化学名称 | N-{5-[6-fluoro-8-{[4-(2-hydroxypropan-2-yl)piperidin-1-yl]methyl}-2-(morpholin-4-yl)quinazolin-4-yl]-2-methoxypyridin-3-yl}methanesulfonamide |
| 同义词 | Linperlisib; YY-20394; YY 20394; YY20394; PI3Kδ-IN-2; |
| 英文同义词 | Linperlisib; YY-20394; YY 20394; YY20394; PI3Kδ-IN-2; |
| 分子式 | C28H37FN6O5S |
| 分子量 | 588.7 |
| Smile | CS(=O)(NC1=CC(C2=C3C=C(F)C=C(CN4CCC(C(C)(O)C)CC4)C3=NC(N5CCOCC5)=N2)=CN=C1OC)=O |
| InChiKey | NVWKNQGHVMMAJW-UHFFFAOYSA-N |
| InChi | InChI=1S/C28H37FN6O5S/c1-28(2,36)20-5-7-34(8-6-20)17-19-13-21(29)15-22-24(31-27(32-25(19)22)35-9-11-40-12-10-35)18-14-23(33-41(4,37)38)26(39-3)30-16-18/h13-16,20,33,36H,5-12,17H2,1-4H3 |
| Cas号 | 1702816-75-8 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
