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Lerociclib HCl (G1T38 HCl)

编号: 2073106
Cas号: 2097938-59-3
纯度: ≧98.0%

Lerociclib HCl (G1T38 dihydrochloride)是一种分化型口服CDK4 / 6抑制剂,对CDK4 / CyclinD1和CDK6 / CyclinD3的IC50分别为1 nM,2 nM。 Lerociclib HCl (G1T38 dihydrochloride)可以在某些类型的乳腺癌和肺癌中与其他靶向疗法联合使用。

Lerociclib (Free base) , 现货库存, Email联系报价。

仅供研究使用。 我们不向患者出售。

化学信息

名称Lerociclib HCl (G1T38 HCl)
Iupac 化学名称2'-((5-(4-isopropylpiperazin-1-yl)pyridin-2-yl)amino)-7',8'-dihydro-6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-one dihydrochloride
同义词Lerociclib HCl ; G1T38 dihydrochloride ; G1T 38 dihydrochloride
英文同义词Lerociclib HCl ; G1T38 dihydrochloride ; G1T 38 dihydrochloride
分子式C26H36Cl2N8O
分子量547.52
SmileO=C1NCC2(N3C1=CC4=CN=C(NC5=NC=C(N6CCN(C(C)C)CC6)C=C5)N=C43)CCCCC2.[H]Cl.[H]Cl
InChiKeyIUIVDLVJNPANBY-UHFFFAOYSA-N
InChiInChI=1S/C26H34N8O.2ClH/c1-18(2)32-10-12-33(13-11-32)20-6-7-22(27-16-20)30-25-28-15-19-14-21-24(35)29-17-26(8-4-3-5-9-26)34(21)23(19)31-25;;/h6-7,14-16,18H,3-5,8-13,17H2,1-2H3,(H,29,35)(H,27,28,30,31);2*1H
Cas号2097938-59-3
相关CAS号2097938-59-3 (HCl) ;1628256-23-4 (free base)

订购信息

包装价格库存纯度备货期
大货询价询价询价
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外观性状类白色至浅黄色固体
纯度≧98.0%
存储短期可在0-4度保存,数天至数月;长期可在-20度保存三年。
可溶性可溶于DMSO
处理方式Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.
运输条件可在常温下运输
海关编码2933999701
Coming soon.
TargetsCDK4/6 inhibitor
MechanismLerociclib (G1T38 ) is a novel, selective,differentiated oral CDK4/6 inhibitor with biochemical IC50 values of 1 nM, 2 nM and 28 μnM for CDK4, CDK6 and CDK9 respectively. Lerociclib (G1T38) with potential use in combination with other targeted therapies in certain types of breast and lung cancer.
Cell study
Animal study
Clinical study
Not available

化学结构

2073106 - Lerociclib HCl (G1T38 HCl) | CAS 2097938-59-3

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