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Lenalidomide hemihydrate

Catalog No.: 6111409
Cas No.: 847871-99-2
Purity : 98% 
6111409 - Lenalidomide hemihydrate | CAS 847871-99-2

Catalog number : 6111409

CAS number : 847871-99-2

分子式 : C13H14N3O3.5 

分子量 : 268.27 

Iupac 化学名称 : Lenalidomide hemihydrate 

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同义词CC-5013 hemihydrate; CC5013 hemihydrate; CC 5013 hemihydrate 
英文同义词CC-5013 hemihydrate; CC5013 hemihydrate; CC 5013 hemihydrate 
分子式C13H14N3O3.5 
分子量268.27 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
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Lenalidomide (Revlimid, CC-5013) is a TNF- secretion inhibitor with IC50 of 13 nM.

Lenalidomide strongly induces IL-2 and sIL-2R production. Lenalidomide-induced tyrosine phosphorylation of CD28 on T cells is followed by a down-stream activation of NF-B . Lenalidomide and pomalidomide inhibits autoubiquitination of CRBN in HEK293 T cells expressing thalidomide-binding competent wild-type CRBN, but not thalidomide-binding defective CRBN (YW/AA). Overexpression of CRBN wild-type protein, but not CRBN (YW/AA) mutant protein, in KMS12 myeloma cells, amplifies pomalidomide-mediated reductions in c-myc and IRF4 expression and increases in p21(WAF-1) expression. Long-term selection for Lenalidomide resistance in H929 myeloma cell lines is accompanied by a reduction in CRBN, while in DF15R myeloma cells resistant to both pomalidomide and Lenalidomide, CRBN protein is undetectable .

 

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