LY333531
编号: 16122722
Cas号: 169939-93-9
纯度: 98%
LY333531 is a -specific protein kinase C inhibitor. It competitively and reversibly inhibits PKC1 and PKC2 with IC50 values of 4.7 and 5.9 nM respectively.LY333531 strikingly decreases the chance of HUVEC survival and the effect of LY333531 on apoptotic cell death in HUVEC significantly increases compared with the AGEs group. Blockade of PKC-beta up-regulates the expression of Bax and Bad proteins and down-regulates the expression of Bcl-2 protein. Moreover, LY333531 reduces the ratio of Bcl-2/Bax. LY333531 can further prompt AGEs-induced endothelial cells apoptosis. The increased expression of Bax, Bad and decreased expression of Bcl-2 and Bcl-2/Bax ratio are associated with the apoptotic process
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化学信息
| 名称 | LY333531 |
|---|---|
| Iupac 化学名称 | LY333531 |
| 同义词 | Ruboxistaurin |
| 英文同义词 | Ruboxistaurin |
| 分子式 | C28H28N4O3.HCl |
| 分子量 | 505.01 |
| Smile | CN(C)C[C@@H]1CCn2cc(c3c2cccc3)C4=C(c5cn(c6c5cccc6)CCO1)C(=O)NC4=O.Cl |
| InChiKey | NYQIEYDJYFVLPO-FERBBOLQSA-N |
| InChi | InChI=1S/C28H28N4O3.ClH/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24;/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34);1H/t18-;/m0./s1 |
| Cas号 | 169939-93-9 |
| MDL | MFCD00940226 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
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| 大货 | 询价 | 询价 | 询价 |
