LY3009120
编号: 16123041
Cas号: 1454682-72-4
纯度: 98%
LY3009120, also known as DP-4978, is potent and selective pan-RAF inhibitor with potential anticancer activity. LY3009120 showed activities against BRaf or Ras mutant tumor cells . LY3009120 binds to ARaf, BRaf and CRaf isoforms with similar affinity in cells with activating mutations of BRaf or KRas. LY3009120 induces minimal paradoxical pathway activation in NRas or KRas mutant cells. LY3009120 inhibits MEK phosphorylation and cell proliferation in vitro, and exhibits anti-tumor activity in multiple xenograft models carrying mutations in BRaf, NRas or KRas.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | LY3009120 |
|---|---|
| Iupac 化学名称 | LY3009120 |
| 同义词 | LY-3009120; LY 3009120; DP4978; DP 4978; DP-4978 |
| 英文同义词 | LY-3009120; LY 3009120; DP4978; DP 4978; DP-4978 |
| 分子式 | C23H29FN6O |
| 分子量 | 424.52 |
| InChiKey | |
| InChi | |
| Cas号 | 1454682-72-4 |
| 相关CAS号 |
订购信息
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| 大货 | 询价 | 询价 | 询价 |
