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LY2874455

编号: 71801
Cas号: 1254473-64-7
纯度: 98% 

1) Sponsor: Eli Lilly and Company.

2) Phase:  Phase 1

2) LY2874455 is potent, selective, small-molecule FGFR inhibitor.LY2874455 is active against all 4 FGFRs. It exhibits a potent activity against FGF/FGFR-mediated signaling in several cancer cell lines and shows an excellent broad spectrum of antitumor activity in several tumor xenograft models representing the major FGF/FGFR relevant tumor histologies including lung, gastric, and bladder cancers and multiple myeloma, and with a well-defined pharmacokinetic/pharmacodynamic relationship. LY2874455 also exhibits a 6- to 9-fold in vitro and in vivo selectivity on inhibition of FGF- over VEGF-mediated target signaling in mice. Furthermore, LY2874455 did not show VEGF receptor 2-mediated toxicities such as hypertension at efficacious doses. Currently, this molecule is being evaluated for its potential use in the clinic.

 

仅供研究使用。 我们不向患者出售。

化学信息

名称LY2874455
Iupac 化学名称(R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol 
同义词LY2874455,LY 2874455,LY-2874455. 
英文同义词LY2874455,LY 2874455,LY-2874455. 
分子式C21H19Cl2N5O2 
分子量444.31 
SmileC[C@H](C1=C(Cl)C=NC=C1Cl)OC2=CC3=C(NN=C3/C=C/C4=CN(CCO)N=C4)C=C2
InChiKeyGKJCVYLDJWTWQU-CXLRFSCWSA-N
InChiInChI=1S/C21H19Cl2N5O2/c1-13(21-17(22)10-24-11-18(21)23)30-15-3-5-20-16(8-15)19(26-27-20)4-2-14-9-25-28(12-14)6-7-29/h2-5,8-13,29H,6-7H2,1H3,(H,26,27)/b4-2+/t13-/m1/s1
Cas号1254473-64-7
相关CAS号

订购信息

包装价格库存纯度备货期
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外观性状crystalline solid 
纯度98% 
存储3 years -20ºCpowder 6 months-80ºCin solvent 
可溶性Soluble in DMSO 
处理方式
运输条件Shipped under ambient temperature 
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

71801 - LY2874455 | CAS 1254473-64-7

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