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LY2109761

Catalog No.: 16123039
Cas No.: 700874-71-1
Purity : 98% 

LY2109761 is a novel transforming growth factor beta receptor type I and type II dual inhibitor. The effect of LY2109761 has been evaluated on soft agar growth, migration, invasion using a fibroblast coculture model, and detachment-induced apoptosis (anoikis) by Annexin V flow cytometric analysis. The efficacy of LY2109761 on tumor growth, survival, and reduction of spontaneous metastasis have been evaluated in an orthotopic murine model of metastatic pancreatic cancer expressing both luciferase and green fluorescence proteins (L3.6pl/GLT). In vivo, LY2109761 , in combination with gemcitabine, significantly reduced the tumor burden, prolonged survival, and reduced spontaneous abdominal metastases. 

For research use only. We do not sell to patients.

Chemical Information

名称LY2109761
Iupac 化学名称LY2109761 
同义词LY 2109761; LY-2109761 
英文同义词LY 2109761; LY-2109761 
分子式C26H27N5O2 
分子量441.52 
Smilec1ccnc(c1)c2c(c3n(n2)CCC3)c4ccnc5c4ccc(c5)OCCN6CCOCC6
InChiKeyIHLVSLOZUHKNMQ-UHFFFAOYSA-N
InChiInChI=1S/C26H27N5O2/c1-2-9-27-22(4-1)26-25(24-5-3-11-31(24)29-26)21-8-10-28-23-18-19(6-7-20(21)23)33-17-14-30-12-15-32-16-13-30/h1-2,4,6-10,18H,3,5,11-17H2
Cas号700874-71-1
MDLMFCD12923354
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Ordering Information

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Formulationcrystalline solid 
纯度98% 
存储3 years -20ºCpowder 
可溶性Soluble in DMSO 
Handling
运输条件Shipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

16123039 - LY2109761 | CAS 700874-71-1

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