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LY2109761

Catalog No.: 16123039
Cas No.: 700874-71-1
Purity : 98% 
16123039 - LY2109761 | CAS 700874-71-1

Catalog number : 16123039

CAS number : 700874-71-1

分子式 : C26H27N5O2 

分子量 : 441.52 

Iupac 化学名称 : LY2109761 

Smile : c1ccnc(c1)c2c(c3n(n2)CCC3)c4ccnc5c4ccc(c5)OCCN6CCOCC6

InChiKey : IHLVSLOZUHKNMQ-UHFFFAOYSA-N

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同义词LY 2109761; LY-2109761 
英文同义词LY 2109761; LY-2109761 
分子式C26H27N5O2 
分子量441.52 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
Smilec1ccnc(c1)c2c(c3n(n2)CCC3)c4ccnc5c4ccc(c5)OCCN6CCOCC6
InChiKeyIHLVSLOZUHKNMQ-UHFFFAOYSA-N
InChiInChI=1S/C26H27N5O2/c1-2-9-27-22(4-1)26-25(24-5-3-11-31(24)29-26)21-8-10-28-23-18-19(6-7-20(21)23)33-17-14-30-12-15-32-16-13-30/h1-2,4,6-10,18H,3,5,11-17H2
MDLMFCD12923354
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LY2109761 is a novel transforming growth factor beta receptor type I and type II dual inhibitor. The effect of LY2109761 has been evaluated on soft agar growth, migration, invasion using a fibroblast coculture model, and detachment-induced apoptosis (anoikis) by Annexin V flow cytometric analysis. The efficacy of LY2109761 on tumor growth, survival, and reduction of spontaneous metastasis have been evaluated in an orthotopic murine model of metastatic pancreatic cancer expressing both luciferase and green fluorescence proteins (L3.6pl/GLT). In vivo, LY2109761 , in combination with gemcitabine, significantly reduced the tumor burden, prolonged survival, and reduced spontaneous abdominal metastases. 

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