LY2109761
编号: 16123039
Cas号: 700874-71-1
纯度: 98%
LY2109761 is a novel transforming growth factor beta receptor type I and type II dual inhibitor. The effect of LY2109761 has been evaluated on soft agar growth, migration, invasion using a fibroblast coculture model, and detachment-induced apoptosis (anoikis) by Annexin V flow cytometric analysis. The efficacy of LY2109761 on tumor growth, survival, and reduction of spontaneous metastasis have been evaluated in an orthotopic murine model of metastatic pancreatic cancer expressing both luciferase and green fluorescence proteins (L3.6pl/GLT). In vivo, LY2109761 , in combination with gemcitabine, significantly reduced the tumor burden, prolonged survival, and reduced spontaneous abdominal metastases.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | LY2109761 |
|---|---|
| Iupac 化学名称 | LY2109761 |
| 同义词 | LY 2109761; LY-2109761 |
| 英文同义词 | LY 2109761; LY-2109761 |
| 分子式 | C26H27N5O2 |
| 分子量 | 441.52 |
| Smile | c1ccnc(c1)c2c(c3n(n2)CCC3)c4ccnc5c4ccc(c5)OCCN6CCOCC6 |
| InChiKey | IHLVSLOZUHKNMQ-UHFFFAOYSA-N |
| InChi | InChI=1S/C26H27N5O2/c1-2-9-27-22(4-1)26-25(24-5-3-11-31(24)29-26)21-8-10-28-23-18-19(6-7-20(21)23)33-17-14-30-12-15-32-16-13-30/h1-2,4,6-10,18H,3,5,11-17H2 |
| Cas号 | 700874-71-1 |
| MDL | MFCD12923354 |
| 相关CAS号 |
订购信息
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