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LOXO-195

Catalog No.: 185212
Cas No.: 2097002-61-2
Purity : >98%

LOXO-195是一种有效的选择性TRK抑制剂,能够解决在接受larotrectinib (LOXO-101)或多激酶抑制剂的抗TRK活性的患者中可能出现的获得性耐药机制。

For research use only. We do not sell to patients.

Chemical Information

名称LOXO-195
Iupac 化学名称(13E,14E,22R,6R)-35-fluoro-6-methyl-7-aza-1(5,3)-pyrazolo[1,5-a]pyrimidina-3(3,2)-pyridina-2(1,2)-pyrrolidinacyclooctaphan-8-one
同义词LOXO-195; LOXO 195; LOXO195.
英文同义词LOXO-195; LOXO 195; LOXO195.
分子式C20H21FN6O
分子量380.4274
SmileFC1=CN=C(CC[C@@H](C)NC(C2=C3N(C=CC4=N3)N=C2)=O)C([C@@H]5N4CCC5)=C1
InChiKeyOEBIHOVSAMBXIB-SJKOYZFVSA-N
InChiInChI=1S/C20H21FN6O/c1-12-4-5-16-14(9-13(21)10-22-16)17-3-2-7-26(17)18-6-8-27-19(25-18)15(11-23-27)20(28)24-12/h6,8-12,17H,2-5,7H2,1H3,(H,24,28)/t12-,17-/m1/s1
Cas号2097002-61-2
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Ordering Information

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Formulation 类白色至白色固体
纯度>98%
存储短期可在0-4度保存,数天至数月;长期可在-20度保存三年。
可溶性可溶于DMSO
Handling
运输条件可在常温下运输
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

185212 - LOXO-195 | CAS 2097002-61-2

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