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LML-134

Catalog No.: 2051510
Cas No.: 1542135-76-1
Purity : 98% Min.
2051510 - LML-134 | CAS 1542135-76-1

Catalog number : 2051510

CAS number : 1542135-76-1

分子式 : C19H29N5O3

分子量 : 375.473

Iupac 化学名称 : 1-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)piperidin-4-yl 4-cyclobutylpiperazine-1-carboxylate

Smile : O=C(N1CCN(C2CCC2)CC1)OC3CCN(C(C=C4)=NN(C)C4=O)CC3

InChiKey : BVUJMFFRMZRNAT-UHFFFAOYSA-N

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同义词LML-134; LML 134; LML134;
英文同义词LML-134; LML 134; LML134;
分子式 C19H29N5O3
分子量375.473
外观固体粉末
纯度98% Min.
可溶性可溶于DMSO
存储干燥、黑暗,短期(日至周)在0-4摄氏度,长期(月至年)在-20摄氏度。
运输条件作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周。
SmileO=C(N1CCN(C2CCC2)CC1)OC3CCN(C(C=C4)=NN(C)C4=O)CC3
InChiKeyBVUJMFFRMZRNAT-UHFFFAOYSA-N
InChiInChI=1S/C19H29N5O3/c1-21-18(25)6-5-17(20-21)23-9-7-16(8-10-23)27-19(26)24-13-11-22(12-14-24)15-3-2-4-15/h5-6,15-16H,2-4,7-14H2,1H3
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 LML134 is an orally active and high selective Histamine 3 receptor (H3R) inverse agonist with Kis of 0.3 nM and 12 nM for hH3R cAMP and hH3R bdg. LML134 is potentially useful for the Clinical Treatment of Excessive Sleep Disorders.


Troxler T, Feuerbach D, Zhang X, et al. The Discovery of LML134, a Histamine H3 Receptor Inverse Agonist for the Clinical Treatment of Excessive Sleep Disorders. ChemMedChem. 2019;14(13):1238–1247. doi:10.1002/cmdc.201900176

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