LDK378(Ceritinib) is potent inhibitor against ALK with IC50 of 0.2 nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively.
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化学信息
| 名称 | LDK378 |
| 分子式 | C28H36ClN5O3S |
| 分子量 | 558.14 |
| InChiKey | |
| InChi | |
| Cas号 | 1032900-25-6 |
| 相关CAS号 | |
| 纯度 | 98% |
| 可溶性 | 10 mM in DMSO |
| 处理方式 | |
| 海关编码 | |
| Targets | |
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study | |