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Ki8751

Catalog No.: 17022703
Cas No.: 228559-41-9
Purity : 98% 
17022703 - Ki8751 | CAS 228559-41-9

Catalog number : 17022703

CAS number : 228559-41-9

分子式 : C24H18F3N3O4 

分子量 : 469.41 

Iupac 化学名称 : 1-(2,4-difluorophenyl)-3-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-2-fluorophenyl)urea 

Smile : FC1=C(C=CC(=C1)F)NC(=O)NC1=C(C=C(C=C1)OC1=CC=NC2=CC(=C(C=C12)OC)OC)F

InChiKey : LFKQSJNCVRGFCC-UHFFFAOYSA-N

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同义词N/A 
英文同义词N/A 
分子式C24H18F3N3O4 
分子量469.41 
外观类白色至白色固体
纯度98% 
可溶性可溶于DMSO;不溶于水
存储短期可在0-4度保存,数天至数月;长期可在-20度保存三年。
运输条件可在常温下运输
SmileFC1=C(C=CC(=C1)F)NC(=O)NC1=C(C=C(C=C1)OC1=CC=NC2=CC(=C(C=C12)OC)OC)F
InChiKeyLFKQSJNCVRGFCC-UHFFFAOYSA-N
InChiInChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
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Ki8751是一种强力的、选择性的VEGFR- 2酪氨酸激酶(IC50 = 0.9 nM)的抑制剂。显示了一些对c - kit,PDGFRα和FGFR-2(IC50值范围从40到170nM)的抑制活动。

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