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Ki16425

Catalog No.: 61121
Cas No.: 355025-24-0
Purity : 98% 
61121 - Ki16425 | CAS 355025-24-0

Catalog number : 61121

CAS number : 355025-24-0

分子式 : C23H23ClN2O5S 

分子量 : 474.96 

Iupac 化学名称 : Ki16425 

Smile : Cc1c(c(on1)c2ccc(cc2)CSCCC(=O)O)NC(=O)OC(C)c3ccccc3Cl

InChiKey : LLIFMNUXGDHTRO-UHFFFAOYSA-N

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同义词Ki-16425; Ki 16425 
英文同义词Ki-16425; Ki 16425 
分子式C23H23ClN2O5S 
分子量474.96 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
SmileCc1c(c(on1)c2ccc(cc2)CSCCC(=O)O)NC(=O)OC(C)c3ccccc3Cl
InChiKeyLLIFMNUXGDHTRO-UHFFFAOYSA-N
InChiInChI=1S/C23H23ClN2O5S/c1-14-21(25-23(29)30-15(2)18-5-3-4-6-19(18)24)22(31-26-14)17-9-7-16(8-10-17)13-32-12-11-20(27)28/h3-10,15H,11-13H2,1-2H3,(H,25,29)(H,27,28)
MDLMFCD06798341
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Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 M, 6.5 M and 0.93 M, respectively, shows no activity at LPA4, LPA5, LPA6.

Kil6425 preferentially inhibits LPA1- and LPA3-mediated responses but has only a moderate effect on LPA2. Ki16425 inhibits the LPA-induced Ca(2+) response in THP-1 cells, 3T3 fibroblasts, and A431 cells, but had only a marginal effect in PC-12 cells and HL-60 cells, which means that Ki16425 seems to be a useful tool for evaluating the involvement of specific LPA receptors in the short-term response to LPA. Ki16425 inhibits long-term DNA synthesis and cell migration as induced by LPA in Swiss 3T3 fibroblasts . Ki16425 reduces the LPA-induced activation of p42/p44 mitogen activated protein kinase (MAPK), while acting as a weak stimulator of p42/p44 MAPK on its own, properties typical of a protean agonist. Ki16425 also significantly reduces the NGF-induced stimulation of p42/p44 MAPK and inhibited NGF-stimulated neurite outgrowth in PC-12 cells .

 

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