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Kenpaullone

Catalog No.: 16122711
Cas No.: 142273-20-9
Purity : 98% 
16122711 - Kenpaullone | CAS 142273-20-9

Catalog number : 16122711

CAS number : 142273-20-9

分子式 : C16H11BrN2O 

分子量 : 327.18 

Iupac 化学名称 : Kenpaullone 

Smile : c1ccc2c(c1)-c3c(c4cc(ccc4[nH]3)Br)CC(=O)N2

InChiKey : QQUXFYAWXPMDOE-UHFFFAOYSA-N

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同义词N/A 
英文同义词N/A 
分子式C16H11BrN2O 
分子量327.18 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
Smilec1ccc2c(c1)-c3c(c4cc(ccc4[nH]3)Br)CC(=O)N2
InChiKeyQQUXFYAWXPMDOE-UHFFFAOYSA-N
InChiInChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20)
MDLMFCD02683595
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Kenpaullone is an ATP-competitive inhibitor of cyclin-dependent kinases (CDKs). It also inhibit glycogen synthase kinase 3 (GSK3) with IC50 of 0.23 M. Kenpaullone also induces the dephosphorylation of both GSK3 isoforms in SH-SY5Y cells and PC12 cells. Kenpaullone (20M) strongly suppresses the autophosphorylation of GSK3 at Tyr216 in vitro whether GSK3 is expressed in Sf21 cells or in E. coli 

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