KW-2449
编号: 16071012
Cas号: 1000669-72-6
纯度: 98% by HPLC
KW-2449 is a novel multikinase inhibitor, which suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Recent research showed that HDACIs increase KW-2449 lethality in Bcr/Abl(+) cells in association with inhibition of Bcr/Abl, generation of ROS, and induction of DNA damage. This strategy preferentially targets primary Bcr/Abl(+) hematopoietic cells and exhibits enhanced in vivo activity. Combining KW-2449 with HDACIs warrants attention in IM-resistant Bcr/Abl(+) leukemias.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | KW-2449 |
|---|---|
| Iupac 化学名称 | (E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone |
| 同义词 | KW2449; KW-2449 |
| 英文同义词 | KW2449; KW-2449 |
| 分子式 | C20H20N4O |
| 分子量 | 332.4 |
| Smile | N1N=C(C2=CC=CC=C12)/C=C/C1=CC=C(C=C1)C(=O)N1CCNCC1 |
| InChiKey | YYLKKYCXAOBSRM-JXMROGBWSA-N |
| InChi | InChI=1S/C20H20N4O/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19/h1-10,21H,11-14H2,(H,22,23)/b10-7+ |
| Cas号 | 1000669-72-6 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
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| 大货 | 询价 | 询价 | 询价 |
