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KU 57788

Catalog No.: 160926003
Cas No.: 503468-95-9
Purity : 98% by HPLC 
160926003 - KU 57788 | CAS 503468-95-9

Catalog number : 160926003

CAS number : 503468-95-9

分子式 : C25H19NO3S 

分子量 : 413.49 

Iupac 化学名称 : 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one 

Smile : C1=CC=C(C=2SC3=C(C21)C=CC=C3)C3=CC=CC=2C(C=C(OC23)N2CCOCC2)=O

InChiKey : JAMULYFATHSZJM-UHFFFAOYSA-N

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同义词NU7441; NU-7441; NU 7441; KU-57788; KU 57788; KU57788. 
英文同义词NU7441; NU-7441; NU 7441; KU-57788; KU 57788; KU57788. 
分子式C25H19NO3S 
分子量413.49 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileC1=CC=C(C=2SC3=C(C21)C=CC=C3)C3=CC=CC=2C(C=C(OC23)N2CCOCC2)=O
InChiKeyJAMULYFATHSZJM-UHFFFAOYSA-N
InChiInChI=1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10,15H,11-14H2
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Potent and selective DNA-PK inhibitor (IC50 = 14 nM). Selective for DNA-PK over a range of kinases including mTOR, PI 3-K, ATM and ATR. Potentiates the effects of doxorubicin andetoposidein vitro and etoposide in vivo. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency 2 to 3-fold, and decreases nonhomologous end-joining (NHEJ) frequency ~40%. 

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