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KRN 633

Catalog No.: 51912
Cas No.: 286370-15-8
Purity : 98% 
51912 - KRN 633 | CAS 286370-15-8

Catalog number : 51912

CAS number : 286370-15-8

分子式 : C20H21ClN4O4 

分子量 : 416.86 

Iupac 化学名称 : 1-(2-chloro-4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-propylurea 

Smile : ClC1=C(C=CC(=C1)OC1=NC=NC2=CC(=C(C=C12)OC)OC)NC(=O)NCCC

InChiKey : VPBYZLCHOKSGRX-UHFFFAOYSA-N

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同义词N/A 
英文同义词N/A 
分子式C20H21ClN4O4 
分子量416.86 
外观white solid 
纯度98% 
可溶性2mg/ml in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature 
SmileClC1=C(C=CC(=C1)OC1=NC=NC2=CC(=C(C=C12)OC)OC)NC(=O)NCCC
InChiKeyVPBYZLCHOKSGRX-UHFFFAOYSA-N
InChiInChI=1S/C20H21ClN4O4/c1-4-7-22-20(26)25-15-6-5-12(8-14(15)21)29-19-13-9-17(27-2)18(28-3)10-16(13)23-11-24-19/h5-6,8-11H,4,7H2,1-3H3,(H2,22,25,26)
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KRN 633 is an ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 170 nM/160 nM/125 nM, weakly inhibits PDGFR-/ and c-Kit, does not block the phosphorylation of FGFR-1, EGFR or c-Met in cell. 

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