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KH-CB19

Catalog No.: 611922
Cas No.: 1354037-26-5
Purity : 98% 
611922 - KH-CB19 | CAS 1354037-26-5

Catalog number : 611922

CAS number : 1354037-26-5

分子式 : C15H13Cl2N3O2 

分子量 : 338.19 

Iupac 化学名称 : KH-CB19 

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同义词KH-CB-19 
英文同义词KH-CB-19 
分子式C15H13Cl2N3O2 
分子量338.19 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
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KH-CB19 is a potent and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4). 


KH-CB19 showed potent inhibition of CLK1 with an IC50 of 20 nM, and for the pure isomer KH-CB19, almost 100-fold selectivity against the CLK3 isoform. Pretreatment of cells with KH-CB19 or TG003 led to a reduction of the TNF--induced increase in phosphorylation of all analyzed SR proteins compared with TNF--stimulated controls.Treatment of resting cells with 10 M KH-CB19 significantly reduced the basal expression of flTF as well as asHTF.



 

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