KH-CB19
编号: 611922
Cas号: 1354037-26-5
纯度: 98%
KH-CB19 is a potent and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).
KH-CB19 showed potent inhibition of CLK1 with an IC50 of 20 nM, and for the pure isomer KH-CB19, almost 100-fold selectivity against the CLK3 isoform. Pretreatment of cells with KH-CB19 or TG003 led to a reduction of the TNF--induced increase in phosphorylation of all analyzed SR proteins compared with TNF--stimulated controls.Treatment of resting cells with 10 M KH-CB19 significantly reduced the basal expression of flTF as well as asHTF.
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化学信息
| 名称 | KH-CB19 |
|---|---|
| Iupac 化学名称 | KH-CB19 |
| 同义词 | KH-CB-19 |
| 英文同义词 | KH-CB-19 |
| 分子式 | C15H13Cl2N3O2 |
| 分子量 | 338.19 |
| InChiKey | |
| InChi | |
| Cas号 | 1354037-26-5 |
| 相关CAS号 |
订购信息
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