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KGP-94

Catalog No.: 3291806
Cas No.: 1131456-28-4
Purity : >98%
3291806 - KGP-94 | CAS 1131456-28-4

Catalog number : 3291806

CAS number : 1131456-28-4

分子式 : C14H12BrN3OS

分子量 : 350.23

Iupac 化学名称 : 2-((3-bromophenyl)(3-hydroxyphenyl)methylene)hydrazinecarbothioamide

Smile : OC1=CC(/C(C2=CC=CC(Br)=C2)=N\NC(N)=S)=CC=C1

InChiKey : ZDBKSZKTCPOBFR-LGMDPLHJSA-N

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同义词KGP-94;KGP94;KGP 94
英文同义词KGP-94;KGP94;KGP 94
分子式C14H12BrN3OS
分子量350.23
外观类白色固体
纯度>98%
可溶性可溶于DMSO;不溶于水
存储Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
运输条件Shipped under ambient temperature
SmileOC1=CC(/C(C2=CC=CC(Br)=C2)=N\NC(N)=S)=CC=C1
InChiKeyZDBKSZKTCPOBFR-LGMDPLHJSA-N
InChiInChI=1S/C14H12BrN3OS/c15-11-5-1-3-9(7-11)13(17-18-14(16)20)10-4-2-6-12(19)8-10/h1-8,19H,(H3,16,18,20)/b17-13-
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KGP94 is a reversible, time-dependent and competitive inhibitor of human cathepsin L. ► KGP94 inhibits the activity of cathepsin L toward human type I collagen. ► KGP94 significantly impedes both migration and invasion of MDA-MB-231 human breast cancer cells. ► Molecular modeling places the thiocarbonyl of KGP94 in proximity to the active site Cys25. ► Significant growth retardation of C3H mouse mammary carcinomas is achieved with KGP94 treatment.

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