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KB-R7943 mesylate

Catalog No.: 16122826
Cas No.: 182004-65-5
Purity : 98% 
16122826 - KB-R7943 mesylate | CAS 182004-65-5

Catalog number : 16122826

CAS number : 182004-65-5

分子式 : C17H21N3O6S2 

分子量 : 427.49 

Iupac 化学名称 : KB-R7943 mesylate 

Smile : CS(=O)(=O)O.c1cc(ccc1CCSC(=N)N)OCc2ccc(cc2)[N+](=O)[O-]

InChiKey : WGIKEBHIKKWJLG-UHFFFAOYSA-N

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同义词KB-R7943; KB R7943; KB-R 7943 
英文同义词KB-R7943; KB R7943; KB-R 7943 
分子式C17H21N3O6S2 
分子量427.49 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
SmileCS(=O)(=O)O.c1cc(ccc1CCSC(=N)N)OCc2ccc(cc2)[N+](=O)[O-]
InChiKeyWGIKEBHIKKWJLG-UHFFFAOYSA-N
InChiInChI=1S/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4)
MDLMFCD00952138
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KB-R7943 is a potent, selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger (IC50 = 0.7 M). KB-R7943 does not modify secondary pathology in the thalamus following focal cerebral stroke in rats. KB-R7943 blocks opening of the mitochondrial permeability transition pore. KB-R7943 restores endothelium-dependent relaxation induced by advanced glycosylation end products in rat aorta. KB-R7943 inhibits high glucose-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion. 

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