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K145

Catalog No.: 6111523
Cas No.: 1309444-75-4
Purity : 98% 
6111523 - K145 | CAS 1309444-75-4

Catalog number : 6111523

CAS number : 1309444-75-4

分子式 : C18H24N2O3S 

分子量 : 348.46 

Iupac 化学名称 : K145 

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同义词SphK2 inhibitor; K 145; K-145 
英文同义词SphK2 inhibitor; K 145; K-145 
分子式C18H24N2O3S 
分子量348.46 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
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K145 is a selective SphK2 inhibitor with an IC50 of 4.300.06 M , while no inhibition of SphK1 at concentrations up to 10 M.

K145 inhibited the activity of SphK2 in a dose-dependent manner with an IC50 of 4.300.06 uM , while no inhibition of SphK1 at concentrations up to 10 uM was observed. Lineweaver-Burk analysis revealed a Ki of 6.40.7 uM for SphK2 and indicated that K145 is a substrate competitive inhibitor (with sphingosine). K145 accumulates in U937 cells, suppresses the S1P level, and inhibits SphK2. K145 also exhibited inhibitory effects on the growth of U937 cells as well as apoptotic effects in U937 cells, and that these effects may be through the inhibition of down-stream ERK and Akt signaling pathways .


K145 also significantly inhibited the growth of U937 tumors in nude mice by both intraperitoneal and oral administration, thus demonstrating its in vivo efficacy as a potential lead anticancer agent .


 

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