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K-858

Catalog No.: 16122824
Cas No.: 72926-24-0
Purity : 98% 

K-858 is a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells. K858 blocked centrosome separation, activated the spindle checkpoint, and induced mitotic arrest in cells accompanied by the formation of monopolar spindles. Long-term continuous treatment of cancer cells with K858 resulted in antiproliferative effects through the induction of mitotic cell death, and polyploidization followed by senescence. K858 exhibited potent antitumor activity in xenograft models of cancer, and induced the accumulation of mitotic cells with monopolar spindles in tumor tissues. 

For research use only. We do not sell to patients.

Chemical Information

名称K-858
Iupac 化学名称K-858 
同义词K 858; K858 
英文同义词K 858; K858 
分子式C13H15N3O2S 
分子量277.342 
SmileCC(=O)NC1=NN(C(S1)(C)c2ccccc2)C(=O)C
InChiKeyJEFVYQYZCAVNTP-UHFFFAOYSA-N
InChiInChI=1S/C13H15N3O2S/c1-9(17)14-12-15-16(10(2)18)13(3,19-12)11-7-5-4-6-8-11/h4-8H,1-3H3,(H,14,15,17)
Cas号72926-24-0
MDLMFCD00181155
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Ordering Information

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Formulationcrystalline solid 
纯度98% 
存储3 years -20ºCpowder 
可溶性Soluble in DMSO 
Handling
运输条件Shipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

16122824 - K-858 | CAS 72926-24-0

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