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K-858

Catalog No.: 16122824
Cas No.: 72926-24-0
Purity : 98% 
16122824 - K-858 | CAS 72926-24-0

Catalog number : 16122824

CAS number : 72926-24-0

分子式 : C13H15N3O2S 

分子量 : 277.342 

Iupac 化学名称 : K-858 

Smile : CC(=O)NC1=NN(C(S1)(C)c2ccccc2)C(=O)C

InChiKey : JEFVYQYZCAVNTP-UHFFFAOYSA-N

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同义词K 858; K858 
英文同义词K 858; K858 
分子式C13H15N3O2S 
分子量277.342 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
SmileCC(=O)NC1=NN(C(S1)(C)c2ccccc2)C(=O)C
InChiKeyJEFVYQYZCAVNTP-UHFFFAOYSA-N
InChiInChI=1S/C13H15N3O2S/c1-9(17)14-12-15-16(10(2)18)13(3,19-12)11-7-5-4-6-8-11/h4-8H,1-3H3,(H,14,15,17)
MDLMFCD00181155
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K-858 is a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells. K858 blocked centrosome separation, activated the spindle checkpoint, and induced mitotic arrest in cells accompanied by the formation of monopolar spindles. Long-term continuous treatment of cancer cells with K858 resulted in antiproliferative effects through the induction of mitotic cell death, and polyploidization followed by senescence. K858 exhibited potent antitumor activity in xenograft models of cancer, and induced the accumulation of mitotic cells with monopolar spindles in tumor tissues. 

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