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JWH-133

Catalog No.: 6111109
Cas No.: 259869-55-1
Purity : 98% 
6111109 - JWH-133 | CAS 259869-55-1

Catalog number : 6111109

CAS number : 259869-55-1

分子式 : C22H32O 

分子量 : 312.49 

Iupac 化学名称 : JWH-133 

Smile : CCCC(C)(C)c1ccc2c(c1)OC([C@H]3[C@H]2CC(=CC3)C)(C)C

InChiKey : YSBFLLZNALVODA-RBUKOAKNSA-N

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同义词JWH133; JWH 133 
英文同义词JWH133; JWH 133 
分子式C22H32O 
分子量312.49 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
SmileCCCC(C)(C)c1ccc2c(c1)OC([C@H]3[C@H]2CC(=CC3)C)(C)C
InChiKeyYSBFLLZNALVODA-RBUKOAKNSA-N
InChiInChI=1S/C22H32O/c1-7-12-21(3,4)16-9-10-17-18-13-15(2)8-11-19(18)22(5,6)23-20(17)14-16/h8-10,14,18-19H,7,11-13H2,1-6H3/t18-,19+/m0/s1
MDLMFCD06795847
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JWH 133 is a potent CB2 selective agonist with Ki of 3.4 nM, 200-fold selective over CB1 receptors.

JWH-133 inhibits IL-12p40 production and enhances IL-10 release by activated macrophages through a CB2 receptor-mediated pathway. a widely used experimental in vitro model to study mechanisms of toxicity and protection in nigral dopaminergic neurons. JWH-133 (10-40 M) induced a concentration-dependent decrease of SH-SY5Y cell viability and proliferation rate.


 

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