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JPH203(KYT-0353)

Catalog No.: 6112701
Cas No.: 1037592-40-7
Purity : 98% by HNMR/HPLC 

JPH203(also known as KYT-0353) is a potent and selective LAT1 selective ( L-type amino acid transporter 1) inhibitor. JPH203 can very potently inhibit l-leucine uptake. JPH203 inhibits YD-38 cell growth. JPH203 up-regulated the population of apoptotic YD-38 cells through the activation of apoptotic factors, including caspases and PARP. 

For research use only. We do not sell to patients.

Chemical Information

名称JPH203(KYT-0353)
Iupac 化学名称(S)-2-amino-3-(4-((5-amino-2-phenylbenzo[d]oxazol-7-yl)methoxy)-3,5-dichlorophenyl)propanoic acid 
同义词JPH203; JPH-203; JPH 203; KYT-0353; KYT 0353; KYT0353 
英文同义词JPH203; JPH-203; JPH 203; KYT-0353; KYT 0353; KYT0353 
分子式C23H19Cl2N3O4 
分子量471.1 
SmileO=C(O)[C@@H](N)CC1=CC(Cl)=C(OCC2=C(OC(C3=CC=CC=C3)=N4)C4=CC(N)=C2)C(Cl)=C1
InChiKeyXNRZJPQTMQZBCE-SFHVURJKSA-N
InChiInChI=1S/C23H19Cl2N3O4/c24-16-6-12(8-18(27)23(29)30)7-17(25)21(16)31-11-14-9-15(26)10-19-20(14)32-22(28-19)13-4-2-1-3-5-13/h1-7,9-10,18H,8,11,26-27H2,(H,29,30)/t18-/m0/s1
Cas号1037592-40-7
Related CAS

Ordering Information

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Formulation淡黄色固体粉末
纯度98% by HNMR/HPLC 
存储3 years -20ºCpowder 6 months-80ºCin solvent 
可溶性Soluble in DMSO, not in water 
Handling
运输条件Shipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1.    Choi DW, Kim DK, Kanai Y, Wempe MF, Endou H,, Kim JK. JPH203, a selective L-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells. Korean J Physiol Pharmacol. 2017 Nov;21(6):599-607. doi: 10.4196/kjpp.2017.21.6.599. Epub 2017 Oct 30.

2.    Muto Y, Furihata T, Kaneko M, Higuchi K, Okunushi K, Morio H, Reien Y, Uesato M, Matsubara H, Anzai N., Different Response Profiles of Gastrointestinal Cancer Cells to an L-Type Amino Acid Transporter Inhibitor, JPH203. Anticancer Res. 2019 Jan;39(1):159-165. doi: 10.21873/anticanres.13092.

3.    Häfliger P, Graff J, Rubin M, Stooss A, Dettmer MS, Altmann KH, Gertsch J, Charles RP.,The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model. J Exp Clin Cancer Res. 2018 Sep 21;37(1):234. doi: 10.1186/s13046-018-0907-z.

4.    Yun DW, Lee SA, Park MG, Kim JS, Yu SK, Park MR, Kim SG, Oh JS, Kim CS, Kim HJ, Kim JS, Chun HS, Kanai Y, Endou H, Wempe MF, Kim DK., JPH203, an L-type amino acid transporter 1-selective compound, induces apoptosis of YD-38 human oral cancer cells. J Pharmacol Sci. 2014;124(2):208-17. Epub 2014 Feb 



化学结构

6112701 - JPH203(KYT-0353) | CAS 1037592-40-7

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