JPH203(KYT-0353)
JPH203(also known as KYT-0353) is a potent and selective LAT1 selective ( L-type amino acid transporter 1) inhibitor. JPH203 can very potently inhibit l-leucine uptake. JPH203 inhibits YD-38 cell growth. JPH203 up-regulated the population of apoptotic YD-38 cells through the activation of apoptotic factors, including caspases and PARP.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | JPH203(KYT-0353) |
|---|---|
| Iupac 化学名称 | (S)-2-amino-3-(4-((5-amino-2-phenylbenzo[d]oxazol-7-yl)methoxy)-3,5-dichlorophenyl)propanoic acid |
| 同义词 | JPH203 ; JPH-203 ; JPH 203 ; KYT-0353 ; KYT 0353 ; KYT0353 |
| 英文同义词 | JPH203 ; JPH-203 ; JPH 203 ; KYT-0353 ; KYT 0353 ; KYT0353 |
| 分子式 | C23H19Cl2N3O4 |
| 分子量 | 471.1 |
| Smile | O=C(O)[C@@H](N)CC1=CC(Cl)=C(OCC2=C(OC(C3=CC=CC=C3)=N4)C4=CC(N)=C2)C(Cl)=C1 |
| InChiKey | XNRZJPQTMQZBCE-SFHVURJKSA-N |
| InChi | InChI=1S/C23H19Cl2N3O4/c24-16-6-12(8-18(27)23(29)30)7-17(25)21(16)31-11-14-9-15(26)10-19-20(14)32-22(28-19)13-4-2-1-3-5-13/h1-7,9-10,18H,8,11,26-27H2,(H,29,30)/t18-/m0/s1 |
| Cas号 | 1037592-40-7 |
| 相关CAS号 | 1597402-27-1 (2HCl) 1037592-40-7 (free base) |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 淡黄色固体粉末 |
|---|---|
| 纯度 | ≧98.0% |
| 存储 | 3 years -20ºCpowder 6 months-80ºCin solvent |
| 可溶性 | Soluble in DMSO, not in water |
| 处理方式 | |
| 运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
| 海关编码 |
| Targets | |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1. Choi DW, Kim DK, Kanai Y, Wempe MF, Endou H,, Kim JK. JPH203, a selective L-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells. Korean J Physiol Pharmacol. 2017 Nov;21(6):599-607. doi: 10.4196/kjpp.2017.21.6.599. Epub 2017 Oct 30.
2. Muto Y, Furihata T, Kaneko M, Higuchi K, Okunushi K, Morio H, Reien Y, Uesato M, Matsubara H, Anzai N., Different Response Profiles of Gastrointestinal Cancer Cells to an L-Type Amino Acid Transporter Inhibitor, JPH203. Anticancer Res. 2019 Jan;39(1):159-165. doi: 10.21873/anticanres.13092.
3. Häfliger P, Graff J, Rubin M, Stooss A, Dettmer MS, Altmann KH, Gertsch J, Charles RP.,The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model. J Exp Clin Cancer Res. 2018 Sep 21;37(1):234. doi: 10.1186/s13046-018-0907-z.
4. Yun DW, Lee SA, Park MG, Kim JS, Yu SK, Park MR, Kim SG, Oh JS, Kim CS, Kim HJ, Kim JS, Chun HS, Kanai Y, Endou H, Wempe MF, Kim DK., JPH203, an L-type amino acid transporter 1-selective compound, induces apoptosis of YD-38 human oral cancer cells. J Pharmacol Sci. 2014;124(2):208-17. Epub 2014 Feb
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