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JNK-IN-8

Catalog No.: 16123027
Cas No.: 1410880-22-6
Purity : 98% 
16123027 - JNK-IN-8 | CAS 1410880-22-6

Catalog number : 16123027

CAS number : 1410880-22-6

分子式 : C29H29N7O2 

分子量 : 507.598 

Iupac 化学名称 : JNK-IN-8 

Smile : Cc1cc(ccc1Nc2nccc(n2)c3cccnc3)NC(=O)c4cccc(c4)NC(=O)/C=C/CN(C)C

InChiKey : GJFCSAPFHAXMSF-UXBLZVDNSA-N

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同义词JNK-IN 8; JNK-IN8; JNK Inhibitor XVI; c-Jun N-terminal Kinase Inhibitor XVI 
英文同义词JNK-IN 8; JNK-IN8; JNK Inhibitor XVI; c-Jun N-terminal Kinase Inhibitor XVI 
分子式C29H29N7O2 
分子量507.598 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
SmileCc1cc(ccc1Nc2nccc(n2)c3cccnc3)NC(=O)c4cccc(c4)NC(=O)/C=C/CN(C)C
InChiKeyGJFCSAPFHAXMSF-UXBLZVDNSA-N
InChiInChI=1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b10-6+
MDLMFCD22124890
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JNK-IN-8, also known as JNK Inhibitor XVI, is a selective JNK inhibitor that inhibits phosphorylation of c-Jun, a direct substrate of JNK, in cells exposed to submicromolar drug in a manner that depends on covalent modification of the conserved cysteine residue. Extensive biochemical, cellular, and pathway-based profiling establish the selectivity of JNK-IN-8 for JNK and suggests that the compound will be broadly useful as a pharmacological probe of JNK-dependent signal transduction. 

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