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JNJ-42165279

Catalog No.: 16123025
Cas No.: 1346528-50-4
Purity : 98% 
16123025 - JNJ-42165279 | CAS 1346528-50-4

Catalog number : 16123025

CAS number : 1346528-50-4

分子式 : C18H17ClF2N4O3 

分子量 : 410.81 

Iupac 化学名称 : N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)piperazine-1-carboxamide 

Smile : ClC1=C(C=NC=C1)NC(=O)N1CCN(CC1)CC1=CC2=C(OC(O2)(F)F)C=C1

InChiKey : YWGYNGCRVZLMCS-UHFFFAOYSA-N

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同义词JNJ 42165279; JNJ42165279 
英文同义词JNJ 42165279; JNJ42165279 
分子式C18H17ClF2N4O3 
分子量410.81 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
SmileClC1=C(C=NC=C1)NC(=O)N1CCN(CC1)CC1=CC2=C(OC(O2)(F)F)C=C1
InChiKeyYWGYNGCRVZLMCS-UHFFFAOYSA-N
InChiInChI=1S/C18H17ClF2N4O3/c19-13-3-4-22-10-14(13)23-17(26)25-7-5-24(6-8-25)11-12-1-2-15-16(9-12)28-18(20,21)27-15/h1-4,9-10H,5-8,11H2,(H,23,26)
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JNJ-42165279 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor. JNJ-42165279 covalently inactivates the FAAH enzyme, but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279 exhibited excellent ADME and pharmacodynamic properties as evidenced by its ability to block FAAH in the brain and periphery of rats and thereby cause an elevation of the concentrations of anandamide (AEA), oleoylethanolamide (OEA), and palmitoyl ethanolamide (PEA). JNJ-42165279 was also efficacious in the spinal nerve ligation (SNL) model of neuropathic pain. JNJ-42165279 is currently under clinical trials. 

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