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JNJ-40346527

Catalog No.: 1711221
Cas No.: 1142363-52-7
Purity : >98%
1711221 - JNJ-40346527 | CAS 1142363-52-7

Catalog number : 1711221

CAS number : 1142363-52-7

分子式 : C27H35N5O2

分子量 : 461.61

Iupac 化学名称 : 4-Cyano-1H-imidazole-2-carboxylic acid N-(2-(4,4-dimethylcyclohex-1-enyl)-6-(2,2,6,6-tetramethyltetrahydropyran-4-yl)pyridin-3-yl)amide

Smile : O=C(C1=NC(C#N)=CN1)NC2=CC=C(C3CC(C)(C)OC(C)(C)C3)N=C2C4=CCC(C)(C)CC4

InChiKey : BNVPFDRNGHMRJS-UHFFFAOYSA-N

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同义词JNJ40346527; JNJ 40346527; JNJ-40346527
英文同义词JNJ40346527; JNJ 40346527; JNJ-40346527
分子式C27H35N5O2
分子量461.61
外观 类白色至白色固体
纯度>98%
可溶性可溶于DMSO
存储短期可在0-4度保存,数天至数月;长期可在-20度保存三年。
运输条件可在常温下运输
SmileO=C(C1=NC(C#N)=CN1)NC2=CC=C(C3CC(C)(C)OC(C)(C)C3)N=C2C4=CCC(C)(C)CC4
InChiKeyBNVPFDRNGHMRJS-UHFFFAOYSA-N
InChiInChI=1S/C27H35N5O2/c1-25(2)11-9-17(10-12-25)22-21(32-24(33)23-29-16-19(15-28)30-23)8-7-20(31-22)18-13-26(3,4)34-27(5,6)14-18/h7-9,16,18H,10-14H2,1-6H3,(H,29,30)(H,32,33)
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JNJ-40346527是一种小分子和口服抑制剂,可用于促结肠菌素- 1受体(CSF1R; FMS)具有潜在的抗肿瘤活性。FMS酪氨酸激酶抑制剂JNJ- 40346527阻断了FMS及其配体CSF1的受体配体相互作用,从而阻止了FMS的自磷酸化。

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