JI-101
编号: 16122823
Cas号: 900573-88-8
纯度: 98%
JI-101 is an orally active inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor beta (PDGFRb), and the ephrin B4 receptor B4 (EphB4) with potential antiangiogenic and antineoplastic activities. Angiogenesis inhibitor JI-101 binds to and inhibits VEGFR2, PDGFRb and EphB4, which may inhibit tumor angiogenesis and, so, cellular proliferation in tumor cells overexpressing VEGFR2, PDGFRb and EphB4. The receptor tyrosine kinases VEGFR2, PDGFRb and EphB4 may be overexpressed in a number of different cancer cell types and may play crucial roles in tumor angiogenesis.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | JI-101 |
|---|---|
| Iupac 化学名称 | JI-101 |
| 同义词 | JI101, JI 101 |
| 英文同义词 | JI101, JI 101 |
| 分子式 | C22H20BrN5O2 |
| 分子量 | 466.3305 |
| Smile | COc1ccc(cc1NC(=O)Nc2cccc3c2ccn3Cc4ccnc(c4)N)Br.Cl |
| InChiKey | WWUKDILHPZKGIL-UHFFFAOYSA-N |
| InChi | InChI=1S/C22H20BrN5O2.ClH/c1-30-20-6-5-15(23)12-18(20)27-22(29)26-17-3-2-4-19-16(17)8-10-28(19)13-14-7-9-25-21(24)11-14;/h2-12H,13H2,1H3,(H2,24,25)(H2,26,27,29);1H |
| Cas号 | 900573-88-8 |
| MDL | MFCD18633251 |
| 相关CAS号 |
订购信息
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| 大货 | 询价 | 询价 | 询价 |
