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JI-101

Catalog No.: 16122823
Cas No.: 900573-88-8
Purity : 98% 

JI-101 is an orally active inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor beta (PDGFRb), and the ephrin B4 receptor B4 (EphB4) with potential antiangiogenic and antineoplastic activities. Angiogenesis inhibitor JI-101 binds to and inhibits VEGFR2, PDGFRb and EphB4, which may inhibit tumor angiogenesis and, so, cellular proliferation in tumor cells overexpressing VEGFR2, PDGFRb and EphB4. The receptor tyrosine kinases VEGFR2, PDGFRb and EphB4 may be overexpressed in a number of different cancer cell types and may play crucial roles in tumor angiogenesis. 

For research use only. We do not sell to patients.

Chemical Information

名称JI-101
Iupac 化学名称JI-101 
同义词JI101, JI 101 
英文同义词JI101, JI 101 
分子式C22H20BrN5O2 
分子量466.3305 
SmileCOc1ccc(cc1NC(=O)Nc2cccc3c2ccn3Cc4ccnc(c4)N)Br.Cl
InChiKeyWWUKDILHPZKGIL-UHFFFAOYSA-N
InChiInChI=1S/C22H20BrN5O2.ClH/c1-30-20-6-5-15(23)12-18(20)27-22(29)26-17-3-2-4-19-16(17)8-10-28(19)13-14-7-9-25-21(24)11-14;/h2-12H,13H2,1H3,(H2,24,25)(H2,26,27,29);1H
Cas号900573-88-8
MDLMFCD18633251
Related CAS

Ordering Information

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Formulationcrystalline solid 
纯度98% 
存储3 years -20ºCpowder 
可溶性Soluble in DMSO 
Handling
运输条件Shipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

16122823 - JI-101 | CAS 900573-88-8

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