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JI-101

Catalog No.: 16122823
Cas No.: 900573-88-8
Purity : 98% 
16122823 - JI-101 | CAS 900573-88-8

Catalog number : 16122823

CAS number : 900573-88-8

分子式 : C22H20BrN5O2 

分子量 : 466.3305 

Iupac 化学名称 : JI-101 

Smile : COc1ccc(cc1NC(=O)Nc2cccc3c2ccn3Cc4ccnc(c4)N)Br.Cl

InChiKey : WWUKDILHPZKGIL-UHFFFAOYSA-N

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同义词JI101, JI 101 
英文同义词JI101, JI 101 
分子式C22H20BrN5O2 
分子量466.3305 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
SmileCOc1ccc(cc1NC(=O)Nc2cccc3c2ccn3Cc4ccnc(c4)N)Br.Cl
InChiKeyWWUKDILHPZKGIL-UHFFFAOYSA-N
InChiInChI=1S/C22H20BrN5O2.ClH/c1-30-20-6-5-15(23)12-18(20)27-22(29)26-17-3-2-4-19-16(17)8-10-28(19)13-14-7-9-25-21(24)11-14;/h2-12H,13H2,1H3,(H2,24,25)(H2,26,27,29);1H
MDLMFCD18633251
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JI-101 is an orally active inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor beta (PDGFRb), and the ephrin B4 receptor B4 (EphB4) with potential antiangiogenic and antineoplastic activities. Angiogenesis inhibitor JI-101 binds to and inhibits VEGFR2, PDGFRb and EphB4, which may inhibit tumor angiogenesis and, so, cellular proliferation in tumor cells overexpressing VEGFR2, PDGFRb and EphB4. The receptor tyrosine kinases VEGFR2, PDGFRb and EphB4 may be overexpressed in a number of different cancer cell types and may play crucial roles in tumor angiogenesis. 

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