武汉永璨生物科技有限公司
+86-17702719238 sales@sun-shinechem.com

JAK3-IN-1

编号: 6111506
Cas号: 1805787-93-2
纯度: 98% 

JAK3-IN-1 is a potent JAK3 inhibitor with IC50 of 4.8 nM, also inhibits JAK1 (IC50 = 896 nM) and JAK2 (IC50 = 1050 nM).

JAK3-IN-1 provides a set of useful tools to pharmacologically interrogate JAK3-dependent biology. JAK3-IN-1 completely inhibits IL-4 induced p-STAT6 at a concentration of 500 nM and only partially inhibits IFN-induced p-STAT1 at a concentration of 5.0 M. In a similar way, JAK3-IN-1 exhibits consistent potency and selectivity for JAK3 in leukemia cancer cell lines: TALL-1 and OCL-AML5.

JAK3-IN-1 demonstrates reasonable pharmacokinetic properties, with moderate T1/2 of 1.4 h, area under the curve (AUC) value of 795 ngh/mL following a 10 mg/kg oral dose and good oral
bioavailability of 66%.

 

仅供研究使用。 我们不向患者出售。

化学信息

名称JAK3-IN-1
Iupac 化学名称JAK3-IN-1 
分子式C26H30ClN7O2 
分子量508.02 
InChiKey
InChi
Cas号1805787-93-2
相关CAS号

订购信息

包装价格库存纯度备货期
大货询价询价询价
Request Bulk Quote Download MSDS 电话 : +86-177 0271 9238   Email : sales@sun-shinechem.com
外观性状crystalline solid 
纯度98% 
存储3 years -20ºCpowder 
可溶性Soluble in DMSO 
处理方式
运输条件Shipped under ambient temperature as non-hazardous chemical. 
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

6111506 - JAK3-IN-1 | CAS 1805787-93-2

快速订购

Change