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JAK3-IN-1

Catalog No.: 6111506
Cas No.: 1805787-93-2
Purity : 98% 
6111506 - JAK3-IN-1 | CAS 1805787-93-2

Catalog number : 6111506

CAS number : 1805787-93-2

分子式 : C26H30ClN7O2 

分子量 : 508.02 

Iupac 化学名称 : JAK3-IN-1 

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分子式C26H30ClN7O2 
分子量508.02 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
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JAK3-IN-1 is a potent JAK3 inhibitor with IC50 of 4.8 nM, also inhibits JAK1 (IC50 = 896 nM) and JAK2 (IC50 = 1050 nM).

JAK3-IN-1 provides a set of useful tools to pharmacologically interrogate JAK3-dependent biology. JAK3-IN-1 completely inhibits IL-4 induced p-STAT6 at a concentration of 500 nM and only partially inhibits IFN-induced p-STAT1 at a concentration of 5.0 M. In a similar way, JAK3-IN-1 exhibits consistent potency and selectivity for JAK3 in leukemia cancer cell lines: TALL-1 and OCL-AML5.

JAK3-IN-1 demonstrates reasonable pharmacokinetic properties, with moderate T1/2 of 1.4 h, area under the curve (AUC) value of 795 ngh/mL following a 10 mg/kg oral dose and good oral
bioavailability of 66%.

 

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