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Ivosidenib

Catalog No.: 16053001
Cas No.: 1448347-49-6
Purity : 98% by HPLC 
16053001 - Ivosidenib | CAS 1448347-49-6

Catalog number : 16053001

CAS number : 1448347-49-6

分子式 : C28H22ClF3N6O3 

分子量 : 582.97 

Iupac 化学名称 : (S)-N-((S)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide 

Smile : O=C([C@H](CC1)N(C2=NC=CC(C#N)=C2)C1=O)N([C@@H](C3=CC=CC=C3Cl)C(NC4CC(F)(F)C4)=O)C5=CC(F)=CN=C5

InChiKey : WIJZXSAJMHAVGX-DHLKQENFSA-N

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同义词RG120;RG-120;RG 120;Ivosidenib 
英文同义词RG120;RG-120;RG 120;Ivosidenib 
分子式C28H22ClF3N6O3 
分子量582.97 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileO=C([C@H](CC1)N(C2=NC=CC(C#N)=C2)C1=O)N([C@@H](C3=CC=CC=C3Cl)C(NC4CC(F)(F)C4)=O)C5=CC(F)=CN=C5
InChiKeyWIJZXSAJMHAVGX-DHLKQENFSA-N
InChiInChI=1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)/t22-,25-/m0/s1
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Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells

 

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