Ivosidenib
编号: 16053001
Cas号: 1448347-49-6
纯度: 98% by HPLC
Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells
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化学信息
| 名称 | Ivosidenib |
|---|---|
| Iupac 化学名称 | (S)-N-((S)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide |
| 同义词 | RG120;RG-120;RG 120;Ivosidenib |
| 英文同义词 | RG120;RG-120;RG 120;Ivosidenib |
| 分子式 | C28H22ClF3N6O3 |
| 分子量 | 582.97 |
| Smile | O=C([C@H](CC1)N(C2=NC=CC(C#N)=C2)C1=O)N([C@@H](C3=CC=CC=C3Cl)C(NC4CC(F)(F)C4)=O)C5=CC(F)=CN=C5 |
| InChiKey | WIJZXSAJMHAVGX-DHLKQENFSA-N |
| InChi | InChI=1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)/t22-,25-/m0/s1 |
| Cas号 | 1448347-49-6 |
| 相关CAS号 |
订购信息
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| 大货 | 询价 | 询价 | 询价 |
