Imarikiren
编号: 25093
Cas号: 1202265-63-1
纯度: 98% Min.
Imarikiren, also known as TAK-272, is a potent, selective and orally active direct renin inhibitor for the treatment of diabetic nephropathies. TAK-272 showed potent inhibitory activity against human renin (IC50 = 2.1 nM) in hPRA assay and excellent selectivity against other aspartic proteases, such as pepsin (IC50 > 10 μM) and cathepsin D (IC50 > 10 μM). TAK-272 exhibited a dramatically improved PK profile in rats (F = 25.2%). TAK-272 (3 and 10 mg/kg, p.o.) exhibited potent and long-lasting antihypertensive efficacy in a dose-dependent manner. TAK-272 HCl is currently undergoing human clinical trials.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Imarikiren |
|---|---|
| Iupac 化学名称 | N-isobutyl-1-(4-methoxybutyl)-N-((3S,5R)-5-(morpholine-4-carbonyl)piperidin-3-yl)-1H-benzo[d]imidazole-2-carboxamide |
| 同义词 | IMARIKIREN; TAK-272 free base; TAK-272 free base, (+)-; 01IC75R817; 1202265-63-1 |
| 英文同义词 | IMARIKIREN; TAK-272 free base; TAK-272 free base, (+)-; 01IC75R817; 1202265-63-1 |
| 分子式 | C27H41N5O4 |
| 分子量 | 499.65 |
| Smile | COCCCCN1C2=CC=CC=C2N=C1C(=O)N(CC(C)C)[C@@H]3CNC[C@@H](C3)C(=O)N4CCOCC4 |
| InChiKey | RHIBAIKQWJNESW-YADHBBJMSA-N |
| InChi | InChI=1S/C27H41N5O4/c1-20(2)19-32(22-16-21(17-28-18-22)26(33)30-11-14-36-15-12-30)27(34)25-29-23-8-4-5-9-24(23)31(25)10-6-7-13-35-3/h4-5,8-9,20-22,28H,6-7,10-19H2,1-3H3/t21-,22+/m1/s1 |
| Cas号 | 1202265-63-1 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
