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Idalopirdine (Lu AE58054)

Catalog No.: 16122821
Cas No.: 467459-31-0
Purity : 98% 
16122821 - Idalopirdine (Lu AE58054) | CAS 467459-31-0

Catalog number : 16122821

CAS number : 467459-31-0

分子式 : C20H19F5N2O 

分子量 : 398.377 

Iupac 化学名称 : Idalopirdine (Lu AE58054) 

Smile : c1cc(cc(c1)OCC(C(F)F)(F)F)CNCCc2c[nH]c3c2ccc(c3)F

InChiKey : YBAWYTYNMZWMMJ-UHFFFAOYSA-N

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同义词Lu AE58054; Lu AE-58054; Lu AE 58054; Idalopirdine; Iladopirdine 
英文同义词Lu AE58054; Lu AE-58054; Lu AE 58054; Idalopirdine; Iladopirdine 
分子式C20H19F5N2O 
分子量398.377 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
Smilec1cc(cc(c1)OCC(C(F)F)(F)F)CNCCc2c[nH]c3c2ccc(c3)F
InChiKeyYBAWYTYNMZWMMJ-UHFFFAOYSA-N
InChiInChI=1S/C20H19F5N2O/c21-15-4-5-17-14(11-27-18(17)9-15)6-7-26-10-13-2-1-3-16(8-13)28-12-20(24,25)19(22)23/h1-5,8-9,11,19,26-27H,6-7,10,12H2
MDLMFCD18633269
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Idalopirdine, also known as Lu AE58054 or Iladopirdine, is a potent and selective 5-HT6 receptor antagonist under development by Lundbeck as an augmentation therapy for the treatment of cognitive deficits associated with Alzheimer's disease and schizophrenia. It is in phase III clinical trials. Lu AE58054 displayed high affinity to the human 5-HT(6) receptor (5-HT(6)R) with a Ki of 0.83 nm. Lu AE58054 demonstrated >50-fold selectivity for more than 70 targets examined. Lu AE58054 is a selective antagonist of 5-HT(6)Rs with good oral bioavailability and robust efficacy in a rat model of cognitive impairment in schizophrenia. Lu AE58054 may be useful for the pharmacotherapy of cognitive dysfunction in disease states such as schizophrenia and Alzheimer's disease. 

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