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IU1

Catalog No.: 51637
Cas No.: 314245-33-5
Purity : 98% 
51637 - IU1 | CAS 314245-33-5

Catalog number : 51637

CAS number : 314245-33-5

分子式 : C18H21FN2O 

分子量 : 300.37 

Iupac 化学名称 : 1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone 

Smile : CC1=CC(C(CN2CCCC2)=O)=C(C)N1C3=CC=C(F)C=C3

InChiKey : JUWDSDKJBMFLHE-UHFFFAOYSA-N

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同义词IU1 
英文同义词IU1 
分子式C18H21FN2O 
分子量300.37 
外观light yellow solid 
纯度98% 
可溶性5mg/ml in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature. 
SmileCC1=CC(C(CN2CCCC2)=O)=C(C)N1C3=CC=C(F)C=C3
InChiKeyJUWDSDKJBMFLHE-UHFFFAOYSA-N
InChiInChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3
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IU1 is a reversible and specific inhibitor of proteasome-associating Usp14. It does not inhibit other deubiquitinating enzymes of the 26S proteasome. It partially inhibits the ubiquitin chain trimming activity of the 26S proteasome, which could function to stimulate the degradation of some proteasomal substrates.

 

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