IC261
编号: 611914
Cas号: 186611-52-9
纯度: 98%
IC261 is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 M and for Cdk5 is 4.5 mM.
IC261 is a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. At low micromolar concentrations IC261 inhibits cytokinesis causing a transient mitotic arrest. IC261 selectively inhibits CK1 compared to other protein kinases by an ATP-competitive mechanism.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | IC261 |
|---|---|
| Iupac 化学名称 | IC261 |
| 同义词 | IC-261; SU-5607 |
| 英文同义词 | IC-261; SU-5607 |
| 分子式 | C18H17NO4 |
| 分子量 | 311.33 |
| Smile | COc1cc(c(c(c1)OC)/C=C/2\c3ccccc3NC2=O)OC |
| InChiKey | JBJYTZXCZDNOJW-JLHYYAGUSA-N |
| InChi | InChI=1S/C18H17NO4/c1-21-11-8-16(22-2)14(17(9-11)23-3)10-13-12-6-4-5-7-15(12)19-18(13)20/h4-10H,1-3H3,(H,19,20)/b13-10+ |
| Cas号 | 186611-52-9 |
| MDL | MFCD00118156 |
| 相关CAS号 |
订购信息
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