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HLCL-61

Catalog No.: 16062204
Cas No.: 586395-74-6
Purity : 98% by HPLC 

 HLCL-61 is a potent and selective PRMT5 inhibitor for treatment of acute myeloid leukemia. HLCL-61 resulted in significantly increased expression of miR-29b and consequent suppression of Sp1 and FLT3 in AML (acute myeloid leukemia) cells. As a result, significant antileukemic activity was achieved. The increased PRMT5 activity enhanced AML growth in vitro and in vivo while PRMT5 downregulation reduced it. In AML cells, PRMT5 interacted with Sp1 in a transcription repressor complex and silenced miR-29b preferentially via dimethylation of histone 4 arginine residue H4R3. 

For research use only. We do not sell to patients.

Chemical Information

名称HLCL-61
Iupac 化学名称1-(9-ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride 
同义词HLCL 61; HLCL-61. 
英文同义词HLCL 61; HLCL-61. 
分子式C23H25ClN2O 
分子量380.916 
SmileCl.C(C)N1C2=CC=CC=C2C=2C=C(C=CC12)CNCC1=C(C=CC=C1)OC
InChiKeyXYAVCNMZZKTEGR-UHFFFAOYSA-N
InChiInChI=1S/C23H24N2O.ClH/c1-3-25-21-10-6-5-9-19(21)20-14-17(12-13-22(20)25)15-24-16-18-8-4-7-11-23(18)26-2;/h4-14,24H,3,15-16H2,1-2H3;1H
Cas号586395-74-6
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Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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FormulationSolid powder 
纯度98% by HPLC 
存储-20 ºC for 3 years 
可溶性Soluble in DMSO 
Handling
运输条件Shipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

16062204 - HLCL-61 | CAS 586395-74-6

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