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HLCL-61 HCl

Catalog No.: 16122819
Cas No.: 1158279-20-9
Purity : 98% 
16122819 - HLCL-61 HCl | CAS 1158279-20-9

Catalog number : 16122819

CAS number : 1158279-20-9

分子式 : C23H25ClN2O 

分子量 : 380.916 

Iupac 化学名称 : HLCL-61 HCl 

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同义词HLCL61; HLCL 61; HLCL-61 
英文同义词HLCL61; HLCL 61; HLCL-61 
分子式C23H25ClN2O 
分子量380.916 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
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HLCL-61 is a potent and selective PRMT5 inhibitor for treatment of acute myeloid leukemia. HLCL-61 resulted in significantly increased expression of miR-29b and consequent suppression of Sp1 and FLT3 in AML (acute myeloid leukemia) cells. As a result, significant antileukemic activity was achieved. The increased PRMT5 activity enhanced AML growth in vitro and in vivo while PRMT5 downregulation reduced it. In AML cells, PRMT5 interacted with Sp1 in a transcription repressor complex and silenced miR-29b preferentially via dimethylation of histone 4 arginine residue H4R3. 

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