HA15
编号: 16122816
Cas号: 1609402-14-3
纯度: 98%
HA15 displayed anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors. HA15 also exhibited strong efficacy in xenograft mouse models with melanoma cells either sensitive or resistant to BRAF inhibitors. Transcriptomic, proteomic, and biochemical studies identified the chaperone BiP/GRP78/HSPA5 as the specific target of HA15 and demonstrated that the interaction increases ER stress, leading to melanoma cell death by concomitant induction of autophagic and apoptotic mechanisms.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | HA15 |
|---|---|
| Iupac 化学名称 | HA15 |
| 同义词 | HA-15; HA 15 |
| 英文同义词 | HA-15; HA 15 |
| 分子式 | C23H22N4O3S2 |
| 分子量 | 466.574 |
| Smile | CC(NC1=NC(C2=CC=CC(NS(=O)(C3=C4C=CC=C(N(C)C)C4=CC=C3)=O)=C2)=CS1)=O |
| InChiKey | LBSMEKVVMYSTIH-UHFFFAOYSA-N |
| InChi | InChI=1S/C23H22N4O3S2/c1-15(28)24-23-25-20(14-31-23)16-7-4-8-17(13-16)26-32(29,30)22-12-6-9-18-19(22)10-5-11-21(18)27(2)3/h4-14,26H,1-3H3,(H,24,25,28) |
| Cas号 | 1609402-14-3 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
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| 大货 | 询价 | 询价 | 询价 |
