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HA15

Catalog No.: 16122816
Cas No.: 1609402-14-3
Purity : 98% 
16122816 - HA15 | CAS 1609402-14-3

Catalog number : 16122816

CAS number : 1609402-14-3

分子式 : C23H22N4O3S2 

分子量 : 466.574 

Iupac 化学名称 : HA15 

Smile : CC(NC1=NC(C2=CC=CC(NS(=O)(C3=C4C=CC=C(N(C)C)C4=CC=C3)=O)=C2)=CS1)=O

InChiKey : LBSMEKVVMYSTIH-UHFFFAOYSA-N

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同义词HA-15; HA 15 
英文同义词HA-15; HA 15 
分子式C23H22N4O3S2 
分子量466.574 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
SmileCC(NC1=NC(C2=CC=CC(NS(=O)(C3=C4C=CC=C(N(C)C)C4=CC=C3)=O)=C2)=CS1)=O
InChiKeyLBSMEKVVMYSTIH-UHFFFAOYSA-N
InChiInChI=1S/C23H22N4O3S2/c1-15(28)24-23-25-20(14-31-23)16-7-4-8-17(13-16)26-32(29,30)22-12-6-9-18-19(22)10-5-11-21(18)27(2)3/h4-14,26H,1-3H3,(H,24,25,28)
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HA15 displayed anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors. HA15 also exhibited strong efficacy in xenograft mouse models with melanoma cells either sensitive or resistant to BRAF inhibitors. Transcriptomic, proteomic, and biochemical studies identified the chaperone BiP/GRP78/HSPA5 as the specific target of HA15 and demonstrated that the interaction increases ER stress, leading to melanoma cell death by concomitant induction of autophagic and apoptotic mechanisms. 

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