Gridegalutamide
编号: 25138
Cas号: 2446928-30-7
纯度: 98% Min.
Gridegalutamide, also known as BMS-986365 and CC-94676, is a heterobifunctional, first-in-class, orally bioavailable AR LDD designed to induce rapid, sustained, and highly selective AR degradation in patients who progressed on standard-of-care therapies. AR degrader CC-94676 causes degradation of AR, prevents AR-mediated signaling and inhibits the proliferation of AR-overexpressing tumor cells. AR plays a key role in tumor cell proliferation in castration-resistant prostate cancer (CRPC).
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Gridegalutamide |
|---|---|
| Iupac 化学名称 | (2R)-4-[2-[4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-ethylphenoxy]ethyl]-N-[3-[(2,6-dioxo-3-piperidinyl)amino]phenyl]-2-methyl-1-piperazineacetamide |
| 同义词 | CC-94676, CC94676; CC 94676; BMS-986365; BMS 986365; BMS986365; Gridegalutamide; |
| 英文同义词 | CC-94676, CC94676; CC 94676; BMS-986365; BMS 986365; BMS986365; Gridegalutamide; |
| 分子式 | C41H45F3N8O5S |
| 分子量 | 818.91 |
| Smile | CC(C1=O)(C)N(C2=CC=C(OCCN3C[C@@H](C)N(CC(NC4=CC=CC(NC5C(NC(CC5)=O)=O)=C4)=O)CC3)C(CC)=C2)C(N1C6=CC(C(F)(F)F)=C(C#N)C=C6)=S |
| InChiKey | YUVGVJYLOFTILT-NHYGQJMQSA-N |
| InChi | InChI=1S/C41H45F3N8O5S/c1-5-26-19-31(52-39(58)51(38(56)40(52,3)4)30-10-9-27(22-45)32(21-30)41(42,43)44)11-13-34(26)57-18-17-49-15-16-50(25(2)23-49)24-36(54)47-29-8-6-7-28(20-29)46-33-12-14-35(53)48-37(33)55/h6-11,13,19-21,25,33,46H,5,12,14-18,23-24H2,1-4H3,(H,47,54)(H,48,53,55)/t25-,33?/m1/s1 |
| Cas号 | 2446928-30-7 |
| 相关CAS号 |
订购信息
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