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Golvatinib (E7050)

Catalog No.: 52020
Cas No.: 928037-13-2
Purity : 98% 
52020 - Golvatinib (E7050) | CAS 928037-13-2

Catalog number : 52020

CAS number : 928037-13-2

分子式 : C33H37F2N7O4 

分子量 : 633.69 

Iupac 化学名称 : 1,1-Cyclopropanedicarboxamide, N-[2-fluoro-4-[[2-[[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]amino]-4-pyridinyl]oxy]phenyl]-N'-(4-fluorophenyl)- 

Smile : FC1=C(C=CC(=C1)OC1=CC(=NC=C1)NC(=O)N1CCC(CC1)N1CCN(CC1)C)NC(=O)C1(CC1)C(=O)NC1=CC=C(C=C1)F

InChiKey : UQRCJCNVNUFYDX-UHFFFAOYSA-N

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同义词Golvatinib,E7050 
英文同义词Golvatinib,E7050 
分子式C33H37F2N7O4 
分子量633.69 
外观off-white solid 
纯度98% 
可溶性5mg/ml in DMSO 
存储3 years -20ºCpowder 6 months-80ºCin solvent 
运输条件Shipped under ambient temperature 
SmileFC1=C(C=CC(=C1)OC1=CC(=NC=C1)NC(=O)N1CCC(CC1)N1CCN(CC1)C)NC(=O)C1(CC1)C(=O)NC1=CC=C(C=C1)F
InChiKeyUQRCJCNVNUFYDX-UHFFFAOYSA-N
InChiInChI=1S/C33H37F2N7O4/c1-40-16-18-41(19-17-40)24-9-14-42(15-10-24)32(45)39-29-21-26(8-13-36-29)46-25-6-7-28(27(35)20-25)38-31(44)33(11-12-33)30(43)37-23-4-2-22(34)3-5-23/h2-8,13,20-21,24H,9-12,14-19H2,1H3,(H,37,43)(H,38,44)(H,36,39,45)
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Golvatinib (E7050) is a dual c-Met and VEGFR-2 inhibitor with IC50 of 14 nM and 16 nM, does not inhibit bFGF-stimulated HUVEC growth (up to 1000 nM). Phase 1/2. 

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