Go6976
编号: 16122723
Cas号: 136194-77-9
纯度: 98%
Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKC, and PKC1, respectively. Also a potent inhibitor of JAK2 and Flt3.Go6976 have no effect on the kinase activity of the Ca(2+)-independent PKC subtypes delta, epsilon, and zeta. [1] Beside WT JAK2, Go6976 also inhibits the mutant forms (JAK2 V617F and TEL-JAK2) found in haematological malignancies, and has activity against mutant forms of FLT3. In AML cells, Go6976 reduces the survival to 55% of control in FLT3-ITD cases and to 69% in FLT3-WT samples.[2] Go 6976 potently inhibits HIV-1 induction by Bryostatin 1, tumor necrosis factor alpha, and interleukin 6.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Go6976 |
|---|---|
| Iupac 化学名称 | 3-(13-methyl-5-oxo-6,7-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12(13H)-yl)propanenitrile |
| 同义词 | GO6976; GO-6976; GO 6976; PD406976; PD 406976; PD-406976. |
| 英文同义词 | GO6976; GO-6976; GO 6976; PD406976; PD 406976; PD-406976. |
| 分子式 | C24H18N4O |
| 分子量 | 377.42 |
| Smile | CN1C=2C=CC=CC2C2=C1C=1N(C3=CC=CC=C3C1C1=C2C(NC1)=O)CCC#N |
| InChiKey | VWVYILCFSYNJHF-UHFFFAOYSA-N |
| InChi | InChI=1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29) |
| Cas号 | 136194-77-9 |
| 相关CAS号 |
订购信息
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